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Literature summary extracted from

  • Pucci, S.; Zonetti, M.J.; Fisco, T.; Polidoro, C.; Bocchinfuso, G.; Palleschi, A.; Novelli, G.; Spagnoli, L.G.; Mazzarelli, P.
    Carnitine palmitoyl transferase-1A (CPT1A): a new tumor specific target in human breast cancer (2016), Oncotarget, 12, 19982-19996.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.21 medicine overexpression of the enzyme correlates with a poor overall survival of ovarian cancer patients. CPT1A is a prognostic biomarker and rational target for therapeutic intervention of cancer Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 palmitoyl-CoA + L-carnitine Homo sapiens
-
 CoA + L-palmitoylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Homo sapiens P50416
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 CAOV-3 cell
-
 Homo sapiens
-
2.3.1.21 ovarian cancer cell
-
 Homo sapiens
-
2.3.1.21 ovarian serous carcinoma cell
-
 Homo sapiens
-
2.3.1.21 OVCA-432 cell
-
 Homo sapiens
-
2.3.1.21 OVCAR-3 cell
-
 Homo sapiens
-
2.3.1.21 SKOV-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.21 carnitine palmitoyl transferase-1A
-
 Homo sapiens
2.3.1.21 CPT1A
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.21 malfunction enzyme inactivation inhibits cell growth and ATP production and decreases tumorigenicity of ovarian cancer cells in severe combined immunodeficiency mice Homo sapiens
2.3.1.21 physiological function ovarian cancer cells depend on or are addicted to enzyme-mediated fatty acid beta-oxidation for cell cycle progression Homo sapiens