Literature summary extracted from

Wu, T.P.; Wang, T.; Seetin, M.G.; Lai, Y.; Zhu, S.; Lin, K.; Liu, Y.; Byrum, S.D.; Mackintosh, S.G.; Zhong, M.; Tackett, A.; Wang, G.; Hon, L.S.; Fang, G.; Swenberg, J.A.; Xiao, A.Z.
DNA methylation on N-adenine in mammalian embryonic stem cells (2016), Nature, 532, 329-333.

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.14.11.51	D233A	reduced activity of the recombinant mutant protein	Mus musculus

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
1.14.11.51	Fe2+	contains Fe2+	Mus musculus

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
1.14.11.51	43746	-	x * 43746, calculated from sequence	Mus musculus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.11.51	N6-methyladenine in DNA + 2-oxoglutarate + O2	Mus musculus	the enzyme catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons	adenine in DNA + formaldehyde + succinate + CO2	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.11.51	Mus musculus	P0CB42	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.11.51	embryonic stem cell	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.11.51	N6-methyladenine in DNA + 2-oxoglutarate + O2	-	Mus musculus	adenine in DNA + formaldehyde + succinate + CO2	-	?
1.14.11.51	N6-methyladenine in DNA + 2-oxoglutarate + O2	the enzyme catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons	Mus musculus	adenine in DNA + formaldehyde + succinate + CO2	-	?

Subunits

EC Number	Subunits	Comment	Organism
1.14.11.51	?	x * 43746, calculated from sequence	Mus musculus

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.11.51	ALKBH1	-	Mus musculus

General Information

EC Number	General Information	Comment	Organism
1.14.11.51	physiological function	the enzyme catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons	Mus musculus

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Release 2023.1 (January 2023)