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Literature summary extracted from

  • Wang, B.; Rao, Y.H.; Inoue, M.; Hao, R.; Lai, C.H.; Chen, D.; McDonald, S.L.; Choi, M.C.; Wang, Q.; Shinohara, M.L.; Yao, T.P.
    Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production (2014), Nat. Commun., 5, 3479.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.108 lipopolysaccharide macrophages challenged by bacterial lipopolysaccharides undergo extensive microtubule acetylation Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.108 Mus musculus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.108 RAW-264.7 cell
-
 Mus musculus
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General Information

EC Number General Information Comment Organism
2.3.1.108 physiological function macrophages challenged by bacterial lipopolysaccharides undergo extensive microtubule acetylation. Suppression of lipopolysaccharide-induced microtubule acetylation by inactivating the tubulin acetyltransferase, MEC17, profoundly inhibits the induction of anti-inflammatory interlukin-10, a phenotype effectively reversed by an acetylation-mimicking alpha-tubulin mutant. Reversible microtubule acetylation is a kinase signaling modulator and a key component in the inflammatory response Mus musculus