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Literature summary extracted from

  • Sheldon, J.R.; Marolda, C.L.; Heinrichs, D.E.
    TCA cycle activity in Staphylococcus aureus is essential for iron-regulated synthesis of staphyloferrin A, but not staphyloferrin B: the benefit of a second citrate synthase (2014), Mol. Microbiol., 92, 824-839.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.16 acetyl-CoA + H2O + oxaloacetate Staphylococcus aureus
-
 citrate + CoA
-
 ?
2.3.3.16 acetyl-CoA + H2O + oxaloacetate Staphylococcus aureus Newman
-
 citrate + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.16 Staphylococcus aureus
-
-
-
2.3.3.16 Staphylococcus aureus Newman
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.16 acetyl-CoA + H2O + oxaloacetate
-
 Staphylococcus aureus citrate + CoA
-
 ?
2.3.3.16 acetyl-CoA + H2O + oxaloacetate
-
 Staphylococcus aureus Newman citrate + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.3.16 CitZ
-
 Staphylococcus aureus

Expression

EC Number Organism Comment Expression
2.3.3.16 Staphylococcus aureus enzyme expression is downregulated during iron starvation down

General Information

EC Number General Information Comment Organism
2.3.3.16 malfunction citrate synthase mutants exhibit altered colony morphology with enhanced pigmentation and reduced colony size and enter stationary phase early than the wild type enzyme Staphylococcus aureus
2.3.3.16 metabolism the enzyme is part of the tricarboxylic acid cycle Staphylococcus aureus
2.3.3.16 physiological function the enzyme is required for maximal virulence Staphylococcus aureus