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Literature summary extracted from

  • Zheng, X.; Gai, X.; Ding, F.; Lu, Z.; Tu, K.; Yao, Y.; Liu, Q.
    Histone acetyltransferase PCAF up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling (2013), Mol. Cancer, 12, 96.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.48 nucleus the enzyme is bound to histone H4 in the nucleus of Hep-3B cells Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4 Homo sapiens
-
 CoA + acetylhistone H4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 HEP-3B cell
-
 Homo sapiens
-
2.3.1.48 Hep-G2 cell
-
 Homo sapiens
-
2.3.1.48 hepatocellular carcinoma cell P300/CBP-associated factor expression level analysis Homo sapiens
-
2.3.1.48 Huh-7 cell
-
 Homo sapiens
-
2.3.1.48 PLC/PRF/5 cell
-
 Homo sapiens
-
2.3.1.48 SK-HEP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4
-
 Homo sapiens CoA + acetylhistone H4
-
 ?
2.3.1.48 acetyl-CoA + histone H4 the enzyme PCAF acetylates histone H4 at lysine 8 Homo sapiens CoA + acetylhistone H4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 P300/CBP-associated factor
-
 Homo sapiens
2.3.1.48 PCAF
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.48 malfunction forced expression of PCAF inhibits the growth of hepatocellular carcinoma xenografts, upregulates histone H4 acetylation, suppresses phosphorylation of AKT, and accelerates cell apoptosis. Knockdown of PCAF represses cell apoptosis and accelerates proliferation in Hep-3B cells. Enzyme downregulation in hepatocellular carcinoma tissues is significantly correlated with tumor TNM staging and intrahepatic metastasis Homo sapiens
2.3.1.48 physiological function enzyme PCAF promotes cell apoptosis and functions as a hepatocellular carcinoma repressor through acetylation of histone H4 and inactivation of AKT signaling. Enzyme PCAF regulates acetylation of histone H4 and phosphorylation of AKT in HCC Homo sapiens