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Literature summary extracted from

  • Roy, S.; Nagappa, L.K.; Prahladarao, V.S.; Balaram, H.
    Kinetic mechanism of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase (2015), Mol. Biochem. Parasitol., 204, 111-120.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.2.8 IMP
-
 Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.8 9-deazaguanine uncompetitive inhibitor Plasmodium falciparum
2.4.2.8 GMP competitive inhibitor with respect to guanine, xanthine, and 5-phospho-alpha-D-ribose 1-diphosphate Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.8 0.0016
-
 IMP unactivated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 0.0039
-
 diphosphate unactivated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 0.0042
-
 diphosphate IMP-activated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 0.007
-
 IMP IMP-activated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 0.053
-
 5-phospho-alpha-D-ribose 1-diphosphate IMP-activated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 0.078
-
 xanthine unactivated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 0.101
-
 xanthine IMP-activated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 1.08
-
 5-phospho-alpha-D-ribose 1-diphosphate unactivated enzyme, at pH 7.4 and 23°C Plasmodium falciparum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.8 Mg2+ dependent on Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.8 GMP + diphosphate Plasmodium falciparum
-
 guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.4.2.8 IMP + diphosphate Plasmodium falciparum
-
 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.4.2.8 XMP + diphosphate Plasmodium falciparum
-
 xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.8 Plasmodium falciparum P20035
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.8
-
 Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.8 GMP + diphosphate
-
 Plasmodium falciparum guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.4.2.8 IMP + diphosphate
-
 Plasmodium falciparum hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.4.2.8 xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Plasmodium falciparum XMP + diphosphate
-
 r
2.4.2.8 XMP + diphosphate
-
 Plasmodium falciparum xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.4.2.8 HGXPRT
-
 Plasmodium falciparum
2.4.2.8 hypoxanthine-guanine-xanthine phosphoribosyltransferase
-
 Plasmodium falciparum

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.4.2.8 0.0036
-
 IMP unactivated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 0.0042
-
 IMP IMP-activated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 0.2
-
 5-phospho-alpha-D-ribose 1-diphosphate unactivated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 0.2
-
 xanthine unactivated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 1.6
-
 5-phospho-alpha-D-ribose 1-diphosphate IMP-activated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 1.6
-
 xanthine IMP-activated enzyme, at pH 7.4 and 23°C Plasmodium falciparum

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.4.2.8 0.18
-
 5-phospho-alpha-D-ribose 1-diphosphate unactivated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 0.6
-
 IMP IMP-activated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 0.9
-
 diphosphate unactivated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 1
-
 diphosphate IMP-activated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 2.2
-
 IMP unactivated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 2.6
-
 xanthine unactivated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 16
-
 xanthine IMP-activated enzyme, at pH 7.4 and 23°C Plasmodium falciparum
2.4.2.8 30
-
 5-phospho-alpha-D-ribose 1-diphosphate IMP-activated enzyme, at pH 7.4 and 23°C Plasmodium falciparum