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Literature summary extracted from
- Identification and analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1 and CYP51A1 in cynomolgus macaques (2014), J. Vet. Med. Sci., 76, 1647-1650.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.15.15 | gene CYP27A1, cloned from liver cDNA, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis | Macaca fascicularis |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.15.15 | cholesterol + reduced adrenodoxin + O2 | Macaca fascicularis | - |
27-hydroxycholesterol + oxidized adrenodoxin + H2O | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.15.15 | Macaca fascicularis | B8K1T2 | gene CYP27A1 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.15.15 | adrenal gland | - |
Macaca fascicularis | - |
| 1.14.15.15 | brain | - |
Macaca fascicularis | - |
| 1.14.15.15 | heart | - |
Macaca fascicularis | - |
| 1.14.15.15 | kidney | - |
Macaca fascicularis | - |
| 1.14.15.15 | liver | CYP27A1 is most abundantly expressed in liver | Macaca fascicularis | - |
| 1.14.15.15 | lung | - |
Macaca fascicularis | - |
| 1.14.15.15 | additional information | tissue expression pattern, overview | Macaca fascicularis | - |
| 1.14.15.15 | ovary | - |
Macaca fascicularis | - |
| 1.14.15.15 | small intestine | - |
Macaca fascicularis | - |
| 1.14.15.15 | testis | - |
Macaca fascicularis | - |
| 1.14.15.15 | uterus | - |
Macaca fascicularis | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.15.15 | cholesterol + reduced adrenodoxin + O2 | - |
Macaca fascicularis | 27-hydroxycholesterol + oxidized adrenodoxin + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.15.15 | CYP27A1 | - |
Macaca fascicularis |
| 1.14.15.15 | sterol 27-hydroxylase | - |
Macaca fascicularis |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.15.15 | adrenodoxin | - |
Macaca fascicularis |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.15.15 | physiological function | CYP27A1, sterol 27-hydroxylase, catalyzes the oxidation of cholesterol to 27-hydroxycholesterol in the bile acid biosynthesis and participates in other processes of cholesterol homeostasis. CYP27A1 is also involved in metabolism of vitamin D as vitamin D hydroxylase | Macaca fascicularis |
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Release 2023.1 (January 2023)
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