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Literature summary extracted from

  • Han, F.; Kang, L.Z.; Zeng, X.L.; Ye, Z.W.; Guo, L.Q.; Lin, J.F.
    Bioproduction of baccatin III, an advanced precursor of paclitaxol, with transgenic Flammulina velutipes expressing the 10-deacetylbaccatin III-10-O-acetyl transferase gene (2014), J. Sci. Food Agric., 94, 2376-2383.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.167 synthesis transgenic Flammulina velutipes expressing the DBAT gene is able to produce baccatin III, an advanced precursor of paclitaxel Taxus chinensis

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.167 Taxus chinensis
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-
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2.3.1.167 Taxus chinensis var. mairei
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.167 acetyl-CoA + 10-deacetylbaccatin III
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Taxus chinensis CoA + baccatin III catalyzes the acetylation of the C10 hydroxyl group of the advanced metabolite 10-deacetylbaccatin III to yield baccatin III, which is the immediate diterpenoid precursor of taxol ?
2.3.1.167 acetyl-CoA + 10-deacetylbaccatin III
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Taxus chinensis var. mairei CoA + baccatin III catalyzes the acetylation of the C10 hydroxyl group of the advanced metabolite 10-deacetylbaccatin III to yield baccatin III, which is the immediate diterpenoid precursor of taxol ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.167 10-DAB
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Taxus chinensis
2.3.1.167 DBAT
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Taxus chinensis