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Literature summary extracted from

  • Sabbagh, G.; Berakdar, N.
    Docking studies of flavonoid compounds as inhibitors of beta-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli (2015), J. Mol. Graph. Model., 61, 214-223.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.41 drug development the enzyme is an attractive target for design of antibioticsis related to the elongation of unsat-urated fatty acids in bacterial fatty acid synthesis Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.41 3,6-dihydroxyflavone
-
 Escherichia coli
2.3.1.41 baicalein
-
 Escherichia coli
2.3.1.41 cerulenin irreversible inhibitor of beta-ketoacyl-ACP synthases I and II but is not a selective anti-bacterial because it is also a potent inhibitor of the condensation reaction catalyzed by the mammalian multifunctional (type I) fatty-acidsynthase Escherichia coli
2.3.1.41 daidzein
-
 Escherichia coli
2.3.1.41 eriodictyol
-
 Escherichia coli
2.3.1.41 fisetin
-
 Escherichia coli
2.3.1.41 genistein 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one Escherichia coli
2.3.1.41 homoeriodictyol
-
 Escherichia coli
2.3.1.41 isorhamnetin 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one Escherichia coli
2.3.1.41 luteolin
-
 Escherichia coli
2.3.1.41 additional information screening of 50 flavonoids for inhibition potency against the enzyme, in silico molecular docking study, overview. Only genistein and isorhamnetin show inhibition as well as drug likeliness and bioavailability obeying the Lipinski's guidelines of five. No or poor effects by daidzein, luteolin, herbacetin, petunidin, herbacetin, malvidin, casticin, pinocembrin, kaempferol, butin, 7,3',4',5'-tetramethoxyflavanone, sternbin, galangin, dihydrooroxylin, naringenin, hispidulin, prunetin, 3,6-dihydroxyflavone, tricin, hesperetin, dihydroechioidinin 5,7-dihydroxytrimethoxyflavanone, liquiritigenin, diosmetin, isosakuranetin, dihydrowogonin, syringetin, chrysin, cajanin, naringenin trimethyl ether, pectolinarigenin, 3',4',5',5,7-pentamethoxyflavanone, glycitein, tectorigenin, 4'-hydroxy-5,6,7-trimethoxyflavanone, naringenin 5-methyl ether, 6,2',4'-trimethoxyflavanone, naringenin 7,4'-dimethyl ether, 7-hydroxyflavanone, 5,7-dihydroxyisoflavone, onysilin, and biochanin A Escherichia coli
2.3.1.41 steppogenin
-
 Escherichia coli
2.3.1.41 tamarixetin
-
 Escherichia coli
2.3.1.41 thiolactomicin thiolactomycin is an inhibitor of KAS I and inhibits bacterial cell growth through inhibition of the beta-ketoacyl-ACP synthase activity of type II fatty acids ynthases Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.41 Escherichia coli E2QPI4
-
-

Synonyms

EC Number Synonyms Comment Organism
2.3.1.41 beta-ketoacyl acyl carrier protein synthase I
-
 Escherichia coli
2.3.1.41 KAS I
-
 Escherichia coli