EC Number | Application | Comment | Organism |
---|---|---|---|
2.3.1.180 | drug development | beta-ketoacyl-ACP-synthase III (FabH or KAS III) has become an attractive target for the development of antibacterial agents which can overcome the multidrug resistance | Streptococcus gordonii |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.180 | methyl-CoA disulfide | inhibition mechanism involving enzyme residues His249 and Cys112, overview | Streptococcus gordonii | |
2.3.1.180 | thiolactomycin | - |
Streptococcus gordonii |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.180 | acetyl-CoA + a malonyl-[acyl-carrier protein] | Streptococcus gordonii | - |
an acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2.3.1.180 | acetyl-CoA + a malonyl-[acyl-carrier protein] | Streptococcus gordonii ATCC 35105 | - |
an acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.180 | Streptococcus gordonii | A8AYW5 | - |
- |
2.3.1.180 | Streptococcus gordonii ATCC 35105 | A8AYW5 | - |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.3.1.180 | acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2 | proposed mechanism of condensation reaction in Streptococcus gordonii FabH between catalytic residues His249, Asn279 and Cys112 | Streptococcus gordonii |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.180 | acetyl-CoA + a malonyl-[acyl-carrier protein] | - |
Streptococcus gordonii | an acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
2.3.1.180 | acetyl-CoA + a malonyl-[acyl-carrier protein] | - |
Streptococcus gordonii ATCC 35105 | an acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.1.180 | More | secondary structure elements of the FabH protein, comparison with the enzyme from Enterococcus faecalis, overview | Streptococcus gordonii |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.180 | beta-ketoacyl-ACP-synthase III | - |
Streptococcus gordonii |
2.3.1.180 | FabH | - |
Streptococcus gordonii |
2.3.1.180 | KAS III | - |
Streptococcus gordonii |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.180 | acetyl-CoA | - |
Streptococcus gordonii |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.180 | additional information | active site and substrate binding, ligand binding, molecular dynamics simulations and binding site mapping, detailed overview | Streptococcus gordonii |