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Literature summary extracted from

  • Shamim, A.; Abbasi, S.W.; Azam, S.S.
    Structural and dynamical aspects of Streptococcus gordonii FabH through molecular docking and MD simulations (2015), J. Mol. Graph. Model., 60, 180-196.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.180 drug development beta-ketoacyl-ACP-synthase III (FabH or KAS III) has become an attractive target for the development of antibacterial agents which can overcome the multidrug resistance Streptococcus gordonii

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.180 methyl-CoA disulfide inhibition mechanism involving enzyme residues His249 and Cys112, overview Streptococcus gordonii
2.3.1.180 thiolactomycin
-
Streptococcus gordonii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.180 acetyl-CoA + a malonyl-[acyl-carrier protein] Streptococcus gordonii
-
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
?
2.3.1.180 acetyl-CoA + a malonyl-[acyl-carrier protein] Streptococcus gordonii ATCC 35105
-
an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.180 Streptococcus gordonii A8AYW5
-
-
2.3.1.180 Streptococcus gordonii ATCC 35105 A8AYW5
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.180 acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2 proposed mechanism of condensation reaction in Streptococcus gordonii FabH between catalytic residues His249, Asn279 and Cys112 Streptococcus gordonii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.180 acetyl-CoA + a malonyl-[acyl-carrier protein]
-
Streptococcus gordonii an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
?
2.3.1.180 acetyl-CoA + a malonyl-[acyl-carrier protein]
-
Streptococcus gordonii ATCC 35105 an acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
?

Subunits

EC Number Subunits Comment Organism
2.3.1.180 More secondary structure elements of the FabH protein, comparison with the enzyme from Enterococcus faecalis, overview Streptococcus gordonii

Synonyms

EC Number Synonyms Comment Organism
2.3.1.180 beta-ketoacyl-ACP-synthase III
-
Streptococcus gordonii
2.3.1.180 FabH
-
Streptococcus gordonii
2.3.1.180 KAS III
-
Streptococcus gordonii

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.180 acetyl-CoA
-
Streptococcus gordonii

General Information

EC Number General Information Comment Organism
2.3.1.180 additional information active site and substrate binding, ligand binding, molecular dynamics simulations and binding site mapping, detailed overview Streptococcus gordonii