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Literature summary extracted from

  • Schumacher, F.R.; Wilson, G.; Day, C.L.
    The N-terminal extension of UBE2E ubiquitin-conjugating enzymes limits chain assembly (2013), J. Mol. Biol., 425, 4099-4111.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.2.B8 S68A the mutant shows wild type activity Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.2.B8 21400
-
 1 * 21400, calculated from amino acid sequence Homo sapiens
2.3.2.B8 22400
-
 1 * 22400, SEC-MALS analysis Homo sapiens
2.3.2.25 22400
-
 1 * 22400, calculated from amino acid sequence Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.B8 S-ubiquitinyl-[ubiquitin-carrier protein E2]-L-cysteine + [HECT-E3-ubiquitin-carrier protein]-L-cysteine Homo sapiens
-
 [ubiquitin-carrier protein E2]-L-cysteine + S-ubiquitinyl-[HECT-E3-ubiquitin-carrier protein]-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.B8 Homo sapiens
-
-
-
2.3.2.25 Homo sapiens P51965
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.B8 additional information the full-length UBE2E proteins primarily promote protein monoubiquitylation, whereas the core UBC domain of each can efficiently build polyubiquitin chains Homo sapiens ?
-
 ?
2.3.2.B8 S-ubiquitinyl-[ubiquitin-carrier protein E2]-L-cysteine + [HECT-E3-ubiquitin-carrier protein cIAP2]-L-cysteine
-
 Homo sapiens [ubiquitin-carrier protein E2]-L-cysteine + S-ubiquitinyl-[HECT-E3-ubiquitin-carrier protein cIAP2]-L-cysteine
-
 ?
2.3.2.B8 S-ubiquitinyl-[ubiquitin-carrier protein E2]-L-cysteine + [HECT-E3-ubiquitin-carrier protein]-L-cysteine
-
 Homo sapiens [ubiquitin-carrier protein E2]-L-cysteine + S-ubiquitinyl-[HECT-E3-ubiquitin-carrier protein]-L-cysteine
-
 ?
2.3.2.25 S-ubiquitinyl-[N-terminal E2 ubiquitin-conjugating E2 enzyme]-L-cysteine + [CARP2 protein]-N-terminal-amino acid
-
 Homo sapiens [N-terminal E2 ubiquitin-conjugating enzyme]-L-cysteine + N-ubiquitinyl-[ CARP2 protein]-N-terminal amino acid
-
 ?
2.3.2.25 S-ubiquitinyl-[N-terminal E2 ubiquitin-conjugating E2 enzyme]-L-cysteine + [cIAP2 protein]-N-terminal-amino acid
-
 Homo sapiens [N-terminal E2 ubiquitin-conjugating enzyme]-L-cysteine + N-ubiquitinyl-[ cIAP2 protein]-N-terminal amino acid
-
 ?
2.3.2.25 S-ubiquitinyl-[N-terminal E2 ubiquitin-conjugating E2 enzyme]-L-cysteine + [MDM2 protein]-N-terminal-amino acid
-
 Homo sapiens [N-terminal E2 ubiquitin-conjugating enzyme]-L-cysteine + N-ubiquitinyl-[ MDM2 protein]-N-terminal amino acid
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.2.B8 monomer 1 * 21400, calculated from amino acid sequence Homo sapiens
2.3.2.B8 monomer 1 * 22400, SEC-MALS analysis Homo sapiens
2.3.2.25 monomer 1 * 22400, calculated from amino acid sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.2.B8 UbcH6
-
 Homo sapiens
2.3.2.B8 UBE2E1
-
 Homo sapiens
2.3.2.25 UbcH6
-
 Homo sapiens
2.3.2.25 UBE2E1
-
 Homo sapiens
2.3.2.25 ubiquitin-conjugating enzyme (E2)
-
 Homo sapiens