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Literature summary extracted from

  • Gao, Y.; Nelson, D.W.; Banh, T.; Yen, M.I.; Yen, C.L.
    Intestine-specific expression of MOGAT2 partially restores metabolic efficiency in Mogat2-deficient mice (2013), J. Lipid Res., 54, 1644-1652.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.22 gene MOGAT, expression analysis, recombinant expression in enzyme-deficient mice Homo sapiens
2.3.1.22 gene Mogat2, expression analysis, comparison of the relative expression levels of human MGAT2 in the transgenic mice to those of endogenous mouse MGAT2 in the wild-type mice Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.22 additional information expression of human MGAT2 in the intestine of Mogat2-/- mice promotes the uptake and esterification of monoaclglycerol, and partially restores metabolic efficiency in diet-induced weight gain Mus musculus
2.3.1.22 additional information mice lacking the gene Mogat2 , which codes for an MGAT highly expressed in the small intestine, are resistant to obesity and other metabolic disorders induced by high-fat feeding. The Mogat2-deficient mice absorb normal amounts of dietary fat but exhibit a reduced rate of fat absorption, increased energy expenditure, decreased respiratory exchange ratio, and impaired metabolic efficiency. Recombinant expression of the human gene MOGAT2, encoding the enzyme, in the intestine increases intestinal MGAT activity, restores fat absorption rate, partially corrects energy expenditure, and promotes weight gain upon high-fat feeding. The changes in respiratory exchange ratio are not reverted, and the recoveries in metabolic efficiency and weight gain are incomplete Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.22 acyl-CoA + 2-acylglycerol Homo sapiens
-
 CoA + diacylglycerol
-
 ?
2.3.1.22 acyl-CoA + 2-acylglycerol Mus musculus
-
 CoA + diacylglycerol
-
 ?
2.3.1.22 acyl-CoA + 2-acylglycerol Mus musculus C57/BL6J
-
 CoA + diacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.22 Homo sapiens Q3SYC2 gene MOGAT
-
2.3.1.22 Mus musculus Q80W94 gene Mogat2
-
2.3.1.22 Mus musculus C57/BL6J Q80W94 gene Mogat2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.22 intestine
-
 Homo sapiens
-
2.3.1.22 intestine
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.22 acyl-CoA + 2-acylglycerol
-
 Homo sapiens CoA + diacylglycerol
-
 ?
2.3.1.22 acyl-CoA + 2-acylglycerol
-
 Mus musculus CoA + diacylglycerol
-
 ?
2.3.1.22 acyl-CoA + 2-acylglycerol
-
 Mus musculus C57/BL6J CoA + diacylglycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.22 acyl CoA:monoacylglycerol acyltransferase
-
 Homo sapiens
2.3.1.22 Mgat2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.22 malfunction mice lacking the gene Mogat2 , which codes for an MGAT highly expressed in the small intestine, are resistant to obesity and other metabolic disorders induced by high-fat feeding. The Mogat2-deficient mice absorb normal amounts of dietary fat but exhibit a reduced rate of fat absorption, increased energy expenditure, decreased respiratory exchange ratio, and impaired metabolic efficiency. Recombinant expression of the human gene MOGAT2, encoding the enzyme, in the intestine increases intestinal MGAT activity, restores fat absorption rate, partially corrects energy expenditure, and promotes weight gain upon high-fat feeding. The changes in respiratory exchange ratio are not reverted, and the recoveries in metabolic efficiency and weight gain are incomplete Mus musculus
2.3.1.22 physiological function acyl CoA:monoacylglycerol acyltransferase (MGAT) catalyzes the resynthesis of triacylglycerol, a crucial step in the absorption of dietary fat. MGAT2 in the intestine plays an indispensable role in enhancing metabolic efficiency, in other tissues it may contribute to the regulation of energy metabolism Homo sapiens
2.3.1.22 physiological function acyl CoA:monoacylglycerol acyltransferase (MGAT) catalyzes the resynthesis of triacylglycerol, a crucial step in the absorption of dietary fat. MGAT2 in the intestine plays an indispensable role in enhancing metabolic efficiency, in other tissues it may contribute to the regulation of energy metabolism Mus musculus