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Literature summary extracted from

  • Tomita, K.; Teratani, T.; Suzuki, T.; Shimizu, M.; Sato, H.; Narimatsu, K.; Usui, S.; Furuhashi, H.; Kimura, A.; Nishiyama, K.; Maejima, T.; Okada, Y.; Kurihara, C.; Shimamura, K.; Ebinuma, H.; Saito, H.; Yokoyama, H.; Watanabe, C.; Komoto, S.; Nagao, S.; Sugiyama, K.; Aosasa, S.; Hatsuse, K.; Yamamoto, J.; Hibi, T.; Miura, S.; Hokari, R.; Kanai, T.
    Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells (2014), J. Hepatol., 61, 98-106.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.26 drug development regulation of ACAT1 activities in hepatic stellate cells can be a target for treatment of liver fibrosis Homo sapiens
2.3.1.26 drug development regulation of ACAT1 activities in hepatic stellate cells can be a target for treatment of liver fibrosis Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol Homo sapiens
-
 CoA + cholesterol ester
-
 ?
2.3.1.26 acyl-CoA + cholesterol Mus musculus
-
 CoA + cholesterol ester
-
 ?
2.3.1.26 acyl-CoA + cholesterol Mus musculus C57BL/6
-
 CoA + cholesterol ester
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol Homo sapiens
-
 CoA + cholesterol oleate
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol Mus musculus
-
 CoA + cholesterol oleate
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol Mus musculus C57BL/6
-
 CoA + cholesterol oleate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Homo sapiens P35610
-
-
2.3.1.26 Mus musculus Q61263
-
-
2.3.1.26 Mus musculus C57BL/6 Q61263
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 hepatic stellate cell
-
 Mus musculus
-
2.3.1.26 hepatic stellate cell isozyme ACAT1 is the major isozyme in human primary hepatic stellate cells, little isozyme ACAT2 expression in the cells Homo sapiens
-
2.3.1.26 hepatocyte primary Homo sapiens
-
2.3.1.26 hepatocyte primary Mus musculus
-
2.3.1.26 Kupffer cell
-
 Homo sapiens
-
2.3.1.26 Kupffer cell
-
 Mus musculus
-
2.3.1.26 liver
-
 Homo sapiens
-
2.3.1.26 liver
-
 Mus musculus
-
2.3.1.26 additional information ACAT1 is the major isozyme in mouse primary hepatic stellate cells, and ACAT2 is the major isozyme in mouse primary hepatocytes and Kupffer cells Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol ester
-
 ?
2.3.1.26 acyl-CoA + cholesterol
-
 Mus musculus CoA + cholesterol ester
-
 ?
2.3.1.26 acyl-CoA + cholesterol
-
 Mus musculus C57BL/6 CoA + cholesterol ester
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol oleate
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol
-
 Mus musculus CoA + cholesterol oleate
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol
-
 Mus musculus C57BL/6 CoA + cholesterol oleate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.26 ACAT1
-
 Homo sapiens
2.3.1.26 ACAT1
-
 Mus musculus
2.3.1.26 acyl-CoA:cholesterol acyltransferase 1
-
 Homo sapiens
2.3.1.26 acyl-CoA:cholesterol acyltransferase 1
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.1.26 malfunction ACAT1 deficiency significantly increases free cholesterol levels in hepatic stellate cells, augmenting Toll-like receptor 4, TLR4, protein and downregulating expression of transforming growth factor-beta (TGFbeta) pseudoreceptor Bambi (bone morphogenetic protein and activin membrane-bound inhibitor), leading to sensitization of hepatic stellate cells to TGFbeta activation. Exacerbation of liver fibrosis by ACAT1 deficiency is dependent on free cholesterol accumulation-induced enhancement of TLR4 signaling, effects of ACAT1 deficiency on induced liver fibrosis, overview. ACAT1 deficiency does not affect hepatocellular damage Mus musculus
2.3.1.26 malfunction ACAT1 deficiency significantly increases free cholesterol levels in hepatic stellate cells, augmenting Toll-like receptor 4, TLR4, protein and downregulating expression of transforming growth factor-beta (TGFbeta) pseudoreceptor Bambi (bone morphogenetic protein and activin membrane-bound inhibitor), leading to sensitization of hepatic stellate cells to TGFbeta activation. Exacerbation of liver fibrosis by ACAT1 deficiency is dependent on free cholesterol accumulation-induced enhancement of TLR4 signaling. ACAT1 deficiency does not affect hepatic ACAT2 expression, effects of ACAT1 deficiency on induced liver fibrosis, overview Homo sapiens
2.3.1.26 physiological function acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells, role of ACAT1 in the pathogenesis of liver fibrosis, overview Homo sapiens
2.3.1.26 physiological function acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells, role of ACAT1 in the pathogenesis of liver fibrosis, overview Mus musculus