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Literature summary extracted from

  • Dills, S.S.; Schmidt, M.R.; Saier, M.H.
    Regulation of lactose transport by the phosphoenolpyruvate-sugar phosphotransferase system in membrane vesicles of Escherichia coli (1982), J. Cell. Biochem., 18, 239-244.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.207 D-lactate
-
 Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.207 methyl alpha-glucoside
-
 Escherichia coli
2.7.1.207 additional information substrates of the phosphotransferase system inhibit uptake of lactose. This inhibition is reversed by intravesicular (but not extravesicular) phosphoenolpyruvate. lactose uptake is also inhibited by enzyme IIIGlc preparations that are shocked into the vesicles, and this inhibition is reversed by phosphoenolpyruvate. Enzyme I and HPr neither inhibit nor stimulate lactose uptake Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.207 membrane
-
 Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.207 [protein]-Npi-phospho-L-histidine + lactose[side 1] Escherichia coli
-
 [protein]-L-histidine + lactose 6'-phosphate[side 2]
-
 ?
2.7.1.207 [protein]-Npi-phospho-L-histidine + lactose[side 1] Escherichia coli ML308-225
-
 [protein]-L-histidine + lactose 6'-phosphate[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.207 Escherichia coli
-
-
-
2.7.1.207 Escherichia coli ML308-225
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.207 [protein]-Npi-phospho-L-histidine + lactose[side 1]
-
 Escherichia coli [protein]-L-histidine + lactose 6'-phosphate[side 2]
-
 ?
2.7.1.207 [protein]-Npi-phospho-L-histidine + lactose[side 1]
-
 Escherichia coli ML308-225 [protein]-L-histidine + lactose 6'-phosphate[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.207 lactose permease
-
 Escherichia coli