BRENDA - Enzyme Database show

Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: Metabolic basis and potential clinical implications

Tan, B.; Young, D.; Lu, Z.; Wang, T.; Meier, T.; Shepard, R.; Roth, K.; Zhai, Y.; Huss, K.; Kuo, M.; Gillig, J.; Parthasarathy, S.; Burkholder, T.; Smith, M.; Geeganage, S.; Zhao, G.; J. Biol. Chem. 288, 3500-3511 (2013)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
FK866
specific and potent inhibitor
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.2.12
Homo sapiens
P43490
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
A-2780 cell
-
Homo sapiens
-
2.4.2.12
BxPC-3 cell
-
Homo sapiens
-
2.4.2.12
culture condition:McCoys 5A medium-grown cell
-
Homo sapiens
-
2.4.2.12
DLD-1 cell
-
Homo sapiens
-
2.4.2.12
HCC-1937 cell
-
Homo sapiens
-
2.4.2.12
HCT-116 cell
-
Homo sapiens
-
2.4.2.12
HT-29 cell
-
Homo sapiens
-
2.4.2.12
MDA-MB-231 cell
-
Homo sapiens
-
2.4.2.12
MDA-MB-468 cell
-
Homo sapiens
-
2.4.2.12
SUM-149 cell
-
Homo sapiens
-
2.4.2.12
SW-480 cell
-
Homo sapiens
-
2.4.2.12
U-87MG cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
736436
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
FK866
specific and potent inhibitor
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
A-2780 cell
-
Homo sapiens
-
2.4.2.12
BxPC-3 cell
-
Homo sapiens
-
2.4.2.12
culture condition:McCoys 5A medium-grown cell
-
Homo sapiens
-
2.4.2.12
DLD-1 cell
-
Homo sapiens
-
2.4.2.12
HCC-1937 cell
-
Homo sapiens
-
2.4.2.12
HCT-116 cell
-
Homo sapiens
-
2.4.2.12
HT-29 cell
-
Homo sapiens
-
2.4.2.12
MDA-MB-231 cell
-
Homo sapiens
-
2.4.2.12
MDA-MB-468 cell
-
Homo sapiens
-
2.4.2.12
SUM-149 cell
-
Homo sapiens
-
2.4.2.12
SW-480 cell
-
Homo sapiens
-
2.4.2.12
U-87MG cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
736436
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
2.4.2.12
malfunction
enzyme inhibition is responsible for ATP depletion, metabolic perturbation, and subsequent tumor growth inhibition
Homo sapiens
2.4.2.12
physiological function
the enzyme catalyzes the first rate-limiting step in converting nicotinamide to NAD+, essential for cellular metabolism, energy production, and DNA repair
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.4.2.12
malfunction
enzyme inhibition is responsible for ATP depletion, metabolic perturbation, and subsequent tumor growth inhibition
Homo sapiens
2.4.2.12
physiological function
the enzyme catalyzes the first rate-limiting step in converting nicotinamide to NAD+, essential for cellular metabolism, energy production, and DNA repair
Homo sapiens