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Literature summary extracted from

  • Stock, J.; Waygood, E.; Meadow, N.; Postma, P.; Roseman, S.
    Sugar transport by the bacterial phosphotransferase system. The glucose receptors of the Salmonella typhimurium phosphotransferase system (1982), J. Biol. Chem., 257, 14543-14552.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.191 additional information not inhibited by D-fructose Salmonella enterica

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.191 0.015
-
 D-glucose[side 1] at pH 7.5 and 25°C Salmonella enterica
2.7.1.191 0.02
-
 D-fructose[side 1] at pH 7.5 and 25°C Salmonella enterica
2.7.1.191 0.045
-
 D-mannose[side 1] at pH 7.5 and 25°C Salmonella enterica
2.7.1.191 0.2
-
 2-deoxy-D-glucose[side 1] at pH 7.5 and 25°C Salmonella enterica
2.7.1.199 0.006
-
 methyl alpha-glucoside[side 1] at pH 7.5, temperature not specified in the publication Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.199 0.01
-
 D-glucose[side 1] at pH 7.5, temperature not specified in the publication Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.199 0.04
-
 D-mannose[side 1] at pH 7.5, temperature not specified in the publication Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.199 0.2
-
 2-deoxy-D-glucose[side 1] at pH 7.5, temperature not specified in the publication Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.191 [protein]-Npi-phospho-L-histidine + 2-deoxy-D-glucose[side 1] Salmonella enterica
-
 [protein]-L-histidine + 2-deoxy-D-glucose 6-phosphate[side 2]
-
 ?
2.7.1.191 [protein]-Npi-phospho-L-histidine + D-fructose[side 1] Salmonella enterica
-
 [protein]-L-histidine + D-fructose 6-phosphate[side 2]
-
 ?
2.7.1.191 [protein]-Npi-phospho-L-histidine + D-glucose[side 1] Salmonella enterica
-
 [protein]-L-histidine + D-glucose 6-phosphate[side 2]
-
 ?
2.7.1.191 [protein]-Npi-phospho-L-histidine + D-mannose[side 1] Salmonella enterica
-
 [protein]-L-histidine + D-mannose 6-phosphate[side 2]
-
 ?
2.7.1.199 [protein]-Npi-phospho-L-histidine + D-glucose[side 1] Salmonella enterica subsp. enterica serovar Typhimurium
-
 [protein]-L-histidine + D-glucose 6-phosphate[side 2]
-
 ?
2.7.1.199 [protein]-Npi-phospho-L-histidine + D-glucose[side 1] Salmonella enterica subsp. enterica serovar Typhimurium SB3507
-
 [protein]-L-histidine + D-glucose 6-phosphate[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.191 Salmonella enterica
-
 serovar typhimurium
-
2.7.1.199 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
2.7.1.199 Salmonella enterica subsp. enterica serovar Typhimurium SB3507
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.191 [protein]-Npi-phospho-L-histidine + 2-deoxy-D-glucose[side 1]
-
 Salmonella enterica [protein]-L-histidine + 2-deoxy-D-glucose 6-phosphate[side 2]
-
 ?
2.7.1.191 [protein]-Npi-phospho-L-histidine + D-fructose[side 1]
-
 Salmonella enterica [protein]-L-histidine + D-fructose 6-phosphate[side 2]
-
 ?
2.7.1.191 [protein]-Npi-phospho-L-histidine + D-glucose[side 1]
-
 Salmonella enterica [protein]-L-histidine + D-glucose 6-phosphate[side 2]
-
 ?
2.7.1.191 [protein]-Npi-phospho-L-histidine + D-mannose[side 1]
-
 Salmonella enterica [protein]-L-histidine + D-mannose 6-phosphate[side 2]
-
 ?
2.7.1.199 additional information no activity with D-fructose Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
2.7.1.199 additional information no activity with D-fructose Salmonella enterica subsp. enterica serovar Typhimurium SB3507 ?
-
 ?
2.7.1.199 [protein]-Npi-phospho-L-histidine + 2-deoxy-D-glucose[side 1]
-
 Salmonella enterica subsp. enterica serovar Typhimurium [protein]-L-histidine + 2-deoxy-D-glucose 6-phosphate[side 2]
-
 ?
2.7.1.199 [protein]-Npi-phospho-L-histidine + 2-deoxy-D-glucose[side 1]
-
 Salmonella enterica subsp. enterica serovar Typhimurium SB3507 [protein]-L-histidine + 2-deoxy-D-glucose 6-phosphate[side 2]
-
 ?
2.7.1.199 [protein]-Npi-phospho-L-histidine + D-fructose[side 1] the reaction occurs with high sugar concentrations in vitro Salmonella enterica subsp. enterica serovar Typhimurium [protein]-L-histidine + D-fructose 6-phosphate[side 2]
-
 ?
2.7.1.199 [protein]-Npi-phospho-L-histidine + D-fructose[side 1] the reaction occurs with high sugar concentrations in vitro Salmonella enterica subsp. enterica serovar Typhimurium SB3507 [protein]-L-histidine + D-fructose 6-phosphate[side 2]
-
 ?
2.7.1.199 [protein]-Npi-phospho-L-histidine + D-glucose[side 1]
-
 Salmonella enterica subsp. enterica serovar Typhimurium [protein]-L-histidine + D-glucose 6-phosphate[side 2]
-
 ?
2.7.1.199 [protein]-Npi-phospho-L-histidine + D-glucose[side 1]
-
 Salmonella enterica subsp. enterica serovar Typhimurium SB3507 [protein]-L-histidine + D-glucose 6-phosphate[side 2]
-
 ?
2.7.1.199 [protein]-Npi-phospho-L-histidine + D-mannose[side 1] the reaction occurs with high sugar concentrations in vitro Salmonella enterica subsp. enterica serovar Typhimurium [protein]-L-histidine + D-mannose 6-phosphate[side 2]
-
 ?
2.7.1.199 [protein]-Npi-phospho-L-histidine + D-mannose[side 1] the reaction occurs with high sugar concentrations in vitro Salmonella enterica subsp. enterica serovar Typhimurium SB3507 [protein]-L-histidine + D-mannose 6-phosphate[side 2]
-
 ?
2.7.1.199 [protein]-Npi-phospho-L-histidine + methyl alpha-glucoside[side 1]
-
 Salmonella enterica subsp. enterica serovar Typhimurium [protein]-L-histidine + methyl alpha-glucoside 6-phosphate[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.191 enzyme IIMan
-
 Salmonella enterica
2.7.1.191 ptsM
-
 Salmonella enterica
2.7.1.199 enzyme II-BGlc
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.199 IIGlc
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.199 PtsG
-
 Salmonella enterica subsp. enterica serovar Typhimurium