EC Number | Application | Comment | Organism |
---|---|---|---|
2.3.1.239 | synthesis | substrate engineering approaches to control the catalytic cycle of a full polykeitde synthase module harboring multiple domains. Using alternatively activated native hexaketide substrates, product formation may be controled with greater than 10:1 selectivity for either full module catalysis, leading to a 14-membered macrolactone, or direct cyclization to a 12-membered ring | Streptomyces venezuelae |
2.3.1.240 | synthesis | substrate engineering approaches to control the catalytic cycle of a full polykeitde synthase module harboring multiple domains. Using alternatively activated native hexaketide substrates, product formation may be controled with greater than 10:1 selectivity for either full module catalysis, leading to a 14-membered macrolactone, or direct cyclization to a 12-membered ring | Streptomyces venezuelae |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.239 | Streptomyces venezuelae | - |
- |
- |
2.3.1.239 | Streptomyces venezuelae ATCC 15439 | - |
- |
- |
2.3.1.240 | Streptomyces venezuelae | - |
- |
- |
2.3.1.240 | Streptomyces venezuelae ATCC 15439 | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.239 | (3R,4R,5E,8R,10S,11S,12R)-3-hydroxy-4,8,10,12-tetramethyl-11-[[(2-nitrophenyl)methoxy]methoxy]-13-(phenylsulfanyl)tridec-5-en-7-one + methylmalonyl N-acetylcysteamine | - |
Streptomyces venezuelae | ? | - |
? | |
2.3.1.239 | (3R,4R,5E,8R,10S,11S,12R)-3-hydroxy-4,8,10,12-tetramethyl-11-[[(2-nitrophenyl)methoxy]methoxy]-13-(phenylsulfanyl)tridec-5-en-7-one + methylmalonyl N-acetylcysteamine | - |
Streptomyces venezuelae ATCC 15439 | ? | - |
? | |
2.3.1.239 | additional information | by modification of the type of hexaketide ester employed, product formation may be controled with greater than 10:1 selectivity for either full module catalysis, leading to a 14-membered macrolactone, or direct cyclization to a 12-membered ring | Streptomyces venezuelae | ? | - |
? | |
2.3.1.239 | additional information | by modification of the type of hexaketide ester employed, product formation may be controled with greater than 10:1 selectivity for either full module catalysis, leading to a 14-membered macrolactone, or direct cyclization to a 12-membered ring | Streptomyces venezuelae ATCC 15439 | ? | - |
? | |
2.3.1.239 | N-(2-[[(2R,3S,4S,6R,8E,10R,11R)-11-hydroxy-2,4,6,10-tetramethyl-3-[[(2-nitrophenyl)methoxy]methoxy]-7-oxotridec-8-en-1-yl]sulfanyl]ethyl)acetamide + methylmalonyl N-acetylcysteamine | - |
Streptomyces venezuelae | ? | - |
? | |
2.3.1.239 | N-(2-[[(2R,3S,4S,6R,8E,10R,11R)-11-hydroxy-2,4,6,10-tetramethyl-3-[[(2-nitrophenyl)methoxy]methoxy]-7-oxotridec-8-en-1-yl]sulfanyl]ethyl)acetamide + methylmalonyl N-acetylcysteamine | - |
Streptomyces venezuelae ATCC 15439 | ? | - |
? | |
2.3.1.240 | (3R,4R,5E,8R,10S,11S,12R)-3-hydroxy-4,8,10,12-tetramethyl-11-[[(2-nitrophenyl)methoxy]methoxy]-13-(phenylsulfanyl)tridec-5-en-7-one + methylmalonyl N-acetylcysteamine | - |
Streptomyces venezuelae | ? | - |
? | |
2.3.1.240 | (3R,4R,5E,8R,10S,11S,12R)-3-hydroxy-4,8,10,12-tetramethyl-11-[[(2-nitrophenyl)methoxy]methoxy]-13-(phenylsulfanyl)tridec-5-en-7-one + methylmalonyl N-acetylcysteamine | - |
Streptomyces venezuelae ATCC 15439 | ? | - |
? | |
2.3.1.240 | additional information | by modification of the type of hexaketide ester employed, product formation may be controled with greater than 10:1 selectivity for either full module catalysis, leading to a 14-membered macrolactone, or direct cyclization to a 12-membered ring | Streptomyces venezuelae | ? | - |
? | |
2.3.1.240 | additional information | by modification of the type of hexaketide ester employed, product formation may be controled with greater than 10:1 selectivity for either full module catalysis, leading to a 14-membered macrolactone, or direct cyclization to a 12-membered ring | Streptomyces venezuelae ATCC 15439 | ? | - |
? | |
2.3.1.240 | N-(2-[[(2R,3S,4S,6R,8E,10R,11R)-11-hydroxy-2,4,6,10-tetramethyl-3-[[(2-nitrophenyl)methoxy]methoxy]-7-oxotridec-8-en-1-yl]sulfanyl]ethyl)acetamide + methylmalonyl N-acetylcysteamine | - |
Streptomyces venezuelae | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.239 | type I polyketide synthase PikAIV | - |
Streptomyces venezuelae |
2.3.1.240 | type I polyketide synthase PikAIV | - |
Streptomyces venezuelae |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.239 | additional information | enzyme utilizes an oxidized quinone as co-factor | Streptomyces venezuelae | |
2.3.1.240 | additional information | enzyme utilizes an oxidized quinone as co-factor | Streptomyces venezuelae |