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Literature summary extracted from

  • Martinez Farias, M.A.; Kincaid, V.A.; Annamalai, V.R.; Kiessling, L.L.
    Isoprenoid phosphonophosphates as glycosyltransferase acceptor substrates (2014), J. Am. Chem. Soc., 136, 8492-8495.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.287 Mycobacterium tuberculosis P9WMX3
-
-
2.4.1.287 Mycobacterium tuberculosis ATCC 25618 P9WMX3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.287 additional information enzyme requires a substrate bearing the disaccharide L-Rha-alpha-(1,3)-D-GlcNAc. Phosphonophosphate analogues serve as effective substrates, being processed to lipid-linked oligosaccharides Mycobacterium tuberculosis ?
-
 ?
2.4.1.287 additional information enzyme requires a substrate bearing the disaccharide L-Rha-alpha-(1,3)-D-GlcNAc. Phosphonophosphate analogues serve as effective substrates, being processed to lipid-linked oligosaccharides Mycobacterium tuberculosis ATCC 25618 ?
-
 ?
2.4.1.287 UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1-3)-N-acetyl-alpha-D-glucosaminyl-diphospho-(2Z,6Z)-farnesol synthetic substrate surrogate. Substitution of the farnesol group to isoprenol reduces activity by about 75% Mycobacterium tuberculosis UDP + beta-D-galactofuranosyl-(1-4)-alpha-L-rhamnopyranosyl-(1-3)-N-acetyl-alpha-D-glucosaminyl-diphospho-(2Z,6Z)-farnesol
-
 ?
2.4.1.287 UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1-3)-N-acetyl-alpha-D-glucosaminyl-diphospho-(2Z,6Z)-farnesol synthetic substrate surrogate. Substitution of the farnesol group to isoprenol reduces activity by about 75% Mycobacterium tuberculosis ATCC 25618 UDP + beta-D-galactofuranosyl-(1-4)-alpha-L-rhamnopyranosyl-(1-3)-N-acetyl-alpha-D-glucosaminyl-diphospho-(2Z,6Z)-farnesol
-
 ?
2.4.1.287 UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1-3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol
-
 Mycobacterium tuberculosis UDP + beta-D-galactofuranosyl-(1-4)-alpha-L-rhamnopyranosyl-(1-3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol
-
 ?
2.4.1.287 UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1-3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol
-
 Mycobacterium tuberculosis ATCC 25618 UDP + beta-D-galactofuranosyl-(1-4)-alpha-L-rhamnopyranosyl-(1-3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.287 GlfT1
-
 Mycobacterium tuberculosis