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Literature summary extracted from

  • Song, G.L.; Jin, C.C.; Zhao, W.; Tang, Y.; Wang, Y.L.; Li, M.; Xiao, M.; Li, X.; Li, Q.S.; Lin, X.; Chen, W.W.; Kuang, J.
    Regulation of the RhoA/ROCK/AKT/beta-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma (2016), Int. J. Oncol., 49, 646-656.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.31 NAD+ + protein L-arginine Mus musculus
-
 nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.31 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.31 colon carcinoma cell
-
 Mus musculus
-
2.4.2.31 CT-26 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.31 NAD+ + protein L-arginine
-
 Mus musculus nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.31 arginine-specific ADP-ribosytransferases 1
-
 Mus musculus
2.4.2.31 ART1
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.4.2.31 Mus musculus enzyme expression is increased in colon adenocarcinoma tissues up

General Information

EC Number General Information Comment Organism
2.4.2.31 physiological function the enzyme can regulate epithelial-mesenchymal transition by regulating the RhoA/ROCK1/AKT/beta-catenin pathway and its downstream factors (snail1, vimentin, N-cadherin and E-cadherin) and therefore plays an important role in the progression of colon carcinoma Mus musculus