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Literature summary extracted from

  • Shi, D.; Allewell, N.M.; Tuchman, M.
    The N-acetylglutamate synthase family: structures, function and mechanisms (2015), Int. J. Mol. Sci., 16, 13004-13022.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.1 CoA 50% activity reduction at 2.5 mM Escherichia coli
2.3.1.1 L-arginine 50% activity reduction at 2 mM Escherichia coli
2.3.1.1 N-acetyl-L-glutamate 50% activity reduction at 25 mM Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.1 0.7
-
 acetyl-CoA pH and temperature not specified in the publication Rattus norvegicus
2.3.1.1 1
-
 L-glutamate pH and temperature not specified in the publication Rattus norvegicus
2.3.1.1 4.4
-
 acetyl-CoA pH and temperature not specified in the publication Homo sapiens
2.3.1.1 8.1
-
 L-glutamate pH and temperature not specified in the publication Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.1 190000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.1 acetyl-CoA + L-glutamate Escherichia coli
-
 CoA + N-acetyl-L-glutamate
-
 ?
2.3.1.1 acetyl-CoA + L-glutamate Homo sapiens
-
 CoA + N-acetyl-L-glutamate
-
 ?
2.3.1.1 acetyl-CoA + L-glutamate Rattus norvegicus
-
 CoA + N-acetyl-L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.1 Escherichia coli
-
-
-
2.3.1.1 Homo sapiens
-
-
-
2.3.1.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.1 liver
-
 Homo sapiens
-
2.3.1.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.1 acetyl-CoA + L-glutamate
-
 Escherichia coli CoA + N-acetyl-L-glutamate
-
 ?
2.3.1.1 acetyl-CoA + L-glutamate
-
 Homo sapiens CoA + N-acetyl-L-glutamate
-
 ?
2.3.1.1 acetyl-CoA + L-glutamate
-
 Rattus norvegicus CoA + N-acetyl-L-glutamate
-
 ?
2.3.1.1 additional information the enzyme has little activity with glutamine (5.0%) and glycine (2.9%) and no acetylation of other amino acids (less than 1.0%) as well as low activity with propionyl-CoA (4.3%) and no activity with other acyl-CoA derivatives Escherichia coli ?
-
 ?
2.3.1.1 additional information the enzyme has little activity with glutamine (5.0%) and glycine (2.9%) and no acetylation of other amino acids (less than 1.0%) as well as low activity with propionyl-CoA (4.3%) and no activity with other acyl-CoA derivatives Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.1 N-acetyl-L-glutamate synthase
-
 Escherichia coli
2.3.1.1 N-acetyl-L-glutamate synthase
-
 Homo sapiens
2.3.1.1 N-acetyl-L-glutamate synthase
-
 Rattus norvegicus
2.3.1.1 NAGS
-
 Escherichia coli
2.3.1.1 NAGS
-
 Homo sapiens
2.3.1.1 NAGS
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.1 2
-
 pH and temperature not specified in the publication Escherichia coli L-arginine
2.3.1.1 2.5
-
 pH and temperature not specified in the publication Escherichia coli CoA
2.3.1.1 25
-
 pH and temperature not specified in the publication Escherichia coli N-acetyl-L-glutamate