BRENDA - Enzyme Database show

Nicotinamide phosphoribosyltransferase (NAMPT) activity is essential for survival of resting lymphocytes

Pittelli, M.; Cavone, L.; Lapucci, A.; Oteri, C.; Felici, R.; Niccolai, E.; Amedei, A.; Chiarugi, A.; Immunol. Cell Biol. 92, 191-199 (2014)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
FK866
-
Homo sapiens
2.4.2.12
FK866
-
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Mus musculus
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.2.12
Homo sapiens
P43490
-
-
2.4.2.12
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
lymphocyte
-
Homo sapiens
-
2.4.2.12
lymphocyte
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
736227
Mus musculus
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
736227
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
FK866
-
Homo sapiens
2.4.2.12
FK866
-
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Mus musculus
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
lymphocyte
-
Homo sapiens
-
2.4.2.12
lymphocyte
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
736227
Mus musculus
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
736227
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
2.4.2.12
malfunction
enzyme inhibition induces NAD depletion in various mouse organs but selectively causes dramatic atrophy of the spleen red pulp
Mus musculus
2.4.2.12
physiological function
enzyme activity is essential for survival of resting lymphocytes
Homo sapiens
2.4.2.12
physiological function
enzyme activity is essential for survival of resting lymphocytes
Mus musculus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.4.2.12
malfunction
enzyme inhibition induces NAD depletion in various mouse organs but selectively causes dramatic atrophy of the spleen red pulp
Mus musculus
2.4.2.12
physiological function
enzyme activity is essential for survival of resting lymphocytes
Homo sapiens
2.4.2.12
physiological function
enzyme activity is essential for survival of resting lymphocytes
Mus musculus