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Literature summary extracted from

  • Shirane, K.; Kuji, R.; Tareyanagi, C.; Sato, T.; Kobayashi, Y.; Furukawa, S.; Murata, T.; Kubota, S.; Ishikawa, Y.; Segawa, K.; Furukawa, K.
    Gene expression levels of beta4-galactosyltransferase 5 correlate with the tumorigenic potentials of B16-F10 mouse melanoma cells (2014), Glycobiology, 24, 532-541.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.1.274 medicine the amounts of Lac-Cer synthesized by isoform beta4GalT5 correlate with the tumorigenic potentials of malignantly transformed cells Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.274 UDP-alpha-D-galactose + glucosylceramide Mus musculus
-
 UDP + lactosylceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.274 Mus musculus Q9JMK0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.274 B16-F10 cell
-
 Mus musculus
-
2.4.1.274 B16-F10 cell melanoma cell Mus musculus
-
2.4.1.274 MEF cell
-
 Mus musculus
-
2.4.1.274 melanoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.274 UDP-alpha-D-galactose + glucosylceramide
-
 Mus musculus UDP + lactosylceramide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.274 beta4-galactosyltransferase 5
-
 Mus musculus
2.4.1.274 beta4GalT5
-
 Mus musculus
2.4.1.274 Lac-Cer synthase
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.4.1.274 Mus musculus gene expression increases by 2-3fold upon malignant transformation of cells up

General Information

EC Number General Information Comment Organism
2.4.1.274 physiological function the amounts of Lac-Cer and ganglioside GM3 are significantly less in a stable clone E5 whose beta4GalT5 gene expression level is reduced to 35% than in a control clone C1 by transfection of its antisense cDNA. The average tumor size and average number of colonies formed with clone E5 are decreased to 44 and 49%, respectively, of those formed with clone C1. The numbers and sizes of colonies formed in the soft agarose gels, and the volumes of tumors formed in athymic mice with fibroblasts from wild type, heterozygous and homozygous beta4GalT5-knockout mouse embryos upon transformation with the polyoma virus oncogene correlate with the beta4GalT5 gene dosage Mus musculus