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Literature summary extracted from

  • Tokuda, N.; Numata, S.; Li, X.; Nomura, T.; Takizawa, M.; Kondo, Y.; Yamashita, Y.; Hashimoto, N.; Kiyono, T.; Urano, T.; Furukawa, K.; Furukawa, K.
    beta4GalT6 is involved in the synthesis of lactosylceramide with less intensity than beta4GalT5 (2013), Glycobiology, 23, 1175-1183.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.38 UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide Mus musculus
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 UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.38 Mus musculus
-
-
-
2.4.1.274 Mus musculus
-
-
-
2.4.1.274 Mus musculus Q9JMK0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.38 brain
-
 Mus musculus
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2.4.1.274 fibroblast isoform beta4GalT5 works predominantly in mouse embryonic fibroblasts Mus musculus
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2.4.1.274 kidney male mice show much higher activity of LacCer synthesis than female mice in the kidney. Expression levels of the B4galt5 gene correlate with the LacCer synthase activity in the kidney Mus musculus
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2.4.1.274 additional information expression levels of B4galt6 gene is almost equivalent between male and female mice Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.38 UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
-
 Mus musculus UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.38 beta-1,4-GalT5 isoform Mus musculus
2.4.1.38 beta-1,4-GalT6 isoform Mus musculus
2.4.1.38 beta1,4-galactosyltransferase
-
 Mus musculus
2.4.1.274 B4GalT5
-
 Mus musculus
2.4.1.274 B4GalT6
-
 Mus musculus
2.4.1.274 LacCer synthase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.4.1.38 malfunction gene silencing of isoform beta4GalT5 results in the marked reduction in lactosylceramide synthase activity Mus musculus
2.4.1.38 metabolism the isoform beta4GalT6 plays a role as lactosylceramide synthase, while isoform beta4GalT5 acts as a main enzyme for lactosylceramide biosynthesis Mus musculus
2.4.1.274 physiological function B4galt6 KO mice are born and grow up apparently normal. LacCer synthase activity and the composition of acidic glycosphingolipids in the brain are almost equivalent or minimally different between wild-type and KO mice. B4GalT6 does not act as a major beta4GalT on the modification of glycoproteins Mus musculus