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Literature summary extracted from

  • Barjau Perez-Milicua, M.; Zenteno-Savin, T.; Crocker, D.E.; Gallo-Reynoso, J.P.
    Hypoxanthine-guanine phosphoribosyltransferase and inosine 5-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa) (2015), Front. Physiol., 6, 212.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.205 soluble
-
 Mirounga angustirostris
-
-
1.1.1.205 soluble
-
 Sus scrofa
-
-
1.1.1.205 soluble
-
 Lontra longicaudis annectens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.205 IMP + NAD+ + H2O Mirounga angustirostris
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Sus scrofa
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Lontra longicaudis annectens
-
 XMP + NADH + H+
-
 ?
2.4.2.8 guanine + 5-phospho-alpha-D-ribose 1-diphosphate Sus scrofa
-
 GMP + diphosphate
-
 ?
2.4.2.8 guanine + 5-phospho-alpha-D-ribose 1-diphosphate Lontra longicaudis
-
 GMP + diphosphate
-
 ?
2.4.2.8 guanine + 5-phospho-alpha-D-ribose 1-diphosphate Mirounga angustirostris
-
 GMP + diphosphate
-
 ?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate Sus scrofa
-
 IMP + diphosphate
-
 ?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate Lontra longicaudis
-
 IMP + diphosphate
-
 ?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate Mirounga angustirostris
-
 IMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Lontra longicaudis annectens
-
-
-
1.1.1.205 Mirounga angustirostris
-
-
-
1.1.1.205 Sus scrofa F1SML7 IMPDH1
-
2.4.2.8 Lontra longicaudis
-
-
-
2.4.2.8 Mirounga angustirostris
-
 Northern elephant seal
-
2.4.2.8 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.205 blood plasma
-
 Mirounga angustirostris
-
1.1.1.205 blood plasma
-
 Sus scrofa
-
1.1.1.205 blood plasma
-
 Lontra longicaudis annectens
-
1.1.1.205 erythrocyte
-
 Sus scrofa
-
1.1.1.205 erythrocyte
-
 Lontra longicaudis annectens
-
1.1.1.205 erythrocyte low activity Mirounga angustirostris
-
2.4.2.8 erythrocyte
-
 Sus scrofa
-
2.4.2.8 erythrocyte
-
 Lontra longicaudis
-
2.4.2.8 erythrocyte
-
 Mirounga angustirostris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 IMP + NAD+ + H2O
-
 Mirounga angustirostris XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Sus scrofa XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Lontra longicaudis annectens XMP + NADH + H+
-
 ?
2.4.2.8 guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Sus scrofa GMP + diphosphate
-
 ?
2.4.2.8 guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Lontra longicaudis GMP + diphosphate
-
 ?
2.4.2.8 guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mirounga angustirostris GMP + diphosphate
-
 ?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Sus scrofa IMP + diphosphate
-
 ?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Lontra longicaudis IMP + diphosphate
-
 ?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mirounga angustirostris IMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.205 IMPDH
-
 Mirounga angustirostris
1.1.1.205 IMPDH
-
 Sus scrofa
1.1.1.205 IMPDH
-
 Lontra longicaudis annectens
1.1.1.205 inosine 5-monophosphate dehydrogenase
-
 Mirounga angustirostris
1.1.1.205 inosine 5-monophosphate dehydrogenase
-
 Sus scrofa
1.1.1.205 inosine 5-monophosphate dehydrogenase
-
 Lontra longicaudis annectens
2.4.2.8 HGPRT
-
 Sus scrofa
2.4.2.8 HGPRT
-
 Lontra longicaudis
2.4.2.8 HGPRT
-
 Mirounga angustirostris
2.4.2.8 hypoxanthine-guanine phosphoribosyltransferase
-
 Sus scrofa
2.4.2.8 hypoxanthine-guanine phosphoribosyltransferase
-
 Lontra longicaudis
2.4.2.8 hypoxanthine-guanine phosphoribosyltransferase
-
 Mirounga angustirostris

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.205 NAD+
-
 Mirounga angustirostris
1.1.1.205 NAD+
-
 Sus scrofa
1.1.1.205 NAD+
-
 Lontra longicaudis annectens

General Information

EC Number General Information Comment Organism
1.1.1.205 evolution comparison of enzyme activity and purine metabolite concentration in erythrocytes and plasma from a non-diving mammal (domestic pig) than from diving mammals (river otter and northern elephant seal). IMPDH activity in erythrocytes from domestic pig, Sus scrofa, is higher than that of erythrocytes from river otter, Lontra longicaudis annectens, and northern elephant seal, Mirounga angustirostris. IMPDH activities as well as HX, IMP, XMP and guanine (GDP and GTP), and adenine (AMP, ADP and ATP) nucleotides concentrations in plasma and erythrocytes from diving mammals are lower than those from a non-diving mammal Mirounga angustirostris
1.1.1.205 evolution comparison of enzyme activity and purine metabolite concentration in erythrocytes and plasma from a non-diving mammal (domestic pig) than from diving mammals (river otter and northern elephant seal). IMPDH activity in erythrocytes from domestic pig, Sus scrofa, is higher than that of erythrocytes from river otter, Lontra longicaudis annectens, and northern elephant seal, Mirounga angustirostris. IMPDH activities as well as HX, IMP, XMP and guanine (GDP and GTP), and adenine (AMP, ADP and ATP) nucleotides concentrations in plasma and erythrocytes from diving mammals are lower than those from a non-diving mammal Sus scrofa
1.1.1.205 evolution comparison of enzyme activity and purine metabolite concentration in erythrocytes and plasma from a non-diving mammal (domestic pig) than from diving mammals (river otter and northern elephant seal). IMPDH activity in erythrocytes from domestic pig, Sus scrofa, is higher than that of erythrocytes from river otter, Lontra longicaudis annectens, and northern elephant seal, Mirounga angustirostris. IMPDH activities as well as HX, IMP, XMP and guanine (GDP and GTP), and adenine (AMP, ADP and ATP) nucleotides concentrations in plasma and erythrocytes from diving mammals are lower than those from a non-diving mammal Lontra longicaudis annectens