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Literature summary extracted from

  • Allegretta, G.; Weidel, E.; Empting, M.; Hartmann, R.W.
    Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD (2015), Eur. J. Med. Chem., 90, 351-359.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.230 3-(3,4-dihydroxyphenyl)-N-methylpropanamide potent inhibitor, completely inactive in the cell-based assay Pseudomonas aeruginosa
2.3.1.230 benzyl 3-(3,4-dihydroxyphenyl)propanoate
-
 Pseudomonas aeruginosa
2.3.1.230 methyl 3-(3,4-dihydroxyphenyl)propanoate potent inhibitor Pseudomonas aeruginosa
2.3.1.230 additional information evaluation of selected substrates of the Medicago sativa chalcone synthase CHS2 as potential inhibitors of PqsD. Catechol derivatives possessing an ester moiety are able to reduce the production of 2-heptyl-4(1H)-quinolone in the bacterial cultures without affecting cellular growth Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.230 Pseudomonas aeruginosa P20582
-
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.230 0.0059
-
 pH not specified in the publication, temperature not specified in the publication Pseudomonas aeruginosa benzyl 3-(3,4-dihydroxyphenyl)propanoate
2.3.1.230 0.02
-
 pH not specified in the publication, temperature not specified in the publication Pseudomonas aeruginosa methyl 3-(3,4-dihydroxyphenyl)propanoate
2.3.1.230 0.023
-
 pH not specified in the publication, temperature not specified in the publication Pseudomonas aeruginosa 3-(3,4-dihydroxyphenyl)-N-methylpropanamide