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Literature summary extracted from
- Functional analysis of purine nucleoside phosphorylase as a key enzyme in ribavirin metabolism (2014), Drug Metab. Pharmacokinet., 29, 211-214.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 2.4.2.1 | expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 2.4.2.1 | G51S | the mutant possesses wild type phosphorylase activity levels toward inosine and ribavirin | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.4.2.1 | ganciclovir | - |
Homo sapiens |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 2.4.2.1 | cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 2.4.2.1 | 30000 | - |
x * 30000, SDS-PAGE | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.4.2.1 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 2.4.2.1 | His-Talon column chromatography | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.4.2.1 | liver | - |
Homo sapiens | - |
| 2.4.2.1 | small intestine | high expression | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.2.1 | inosine + phosphate | - |
Homo sapiens | hypoxanthine + alpha-D-ribose 1-phosphate | - |
r | |
| 2.4.2.1 | ribavirin + phosphate | - |
Homo sapiens | 1,2,4-triazole-3-carboxamide + alpha-D-ribose 1-phosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 2.4.2.1 | ? | x * 30000, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.4.2.1 | PNP | - |
Homo sapiens |
| 2.4.2.1 | purine nucleoside phosphorylase | - |
Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 2.4.2.1 | metabolism | key enzyme in ribavirin metabolism of the human small intestine | Homo sapiens |
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Release 2023.1 (January 2023)
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