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Literature summary extracted from

  • Perreault, M.; Gauthier-Landry, L.; Trottier, J.; Verreault, M.; Caron, P.; Finel, M.; Barbier, O.
    The human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation (2013), Drug Metab. Dispos., 41, 1616-1620.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 gene UGT2A1, recombinant expression of C-terminally His-tagged enzyme in Spodoptera frugiperda Sf9 cells via baculovirus transfection Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 additional information
-
 additional information Michaelis-Menten kinetic modeling, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 additional information Homo sapiens the human UGTs of subfamily 2A, UGT2A1, 2A2, and 2A3, show bile acid-conjugating activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
-
-
2.4.1.17 Homo sapiens Q6UWM9
-
-
2.4.1.17 Homo sapiens Q9Y4X1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 additional information the human UGTs of subfamily 2A, UGT2A1, 2A2, and 2A3, show bile acid-conjugating activity Homo sapiens ?
-
 ?
2.4.1.17 additional information activity with all tested bile acids is high with isozyme UGT2A1 Homo sapiens ?
-
 ?
2.4.1.17 additional information activity with all tested bile acids is low with isozyme UGT2A3 Homo sapiens ?
-
 ?
2.4.1.17 UDP-glucuronate + chenodeoxycholic acid
-
 Homo sapiens UDP + chenodeoxycholic acid 24-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + chenodeoxycholic acid best substrate Homo sapiens UDP + chenodeoxycholic acid 24-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + cholic acid
-
 Homo sapiens UDP + cholic acid 24-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + cholic acid best substrate Homo sapiens UDP + cholic acid 24-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + deoxycholic acid
-
 Homo sapiens UDP + deoxycholic acid 24-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + hyocholic acid
-
 Homo sapiens UDP + hyocholic acid 24-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + hyodeoxycholic acid
-
 Homo sapiens UDP + hyodeoxycholic acid 24G-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + lithocholic acid
-
 Homo sapiens UDP + lithocholic acid 3-beta-D-glucuronoside + lithocholic acid 24-beta-D-glucuronoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UGT
-
 Homo sapiens
2.4.1.17 UGT2A1
-
 Homo sapiens
2.4.1.17 UGT2A2
-
 Homo sapiens
2.4.1.17 UGT2A3
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Homo sapiens