BRENDA - Enzyme Database show

The function of nicotinamide phosphoribosyltransferase in the heart

Hsu, C.P.; Yamamoto, T.; Oka, S.; Sadoshima, J.; DNA Repair 23, 64-68 (2014)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.4.2.12
expressed in Mus musculus
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
FK866
-
Homo sapiens
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.4.2.12
52000
-
-
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.2.12
Homo sapiens
P43490
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
heart
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
736003
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.4.2.12
expressed in Mus musculus
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
FK866
-
Homo sapiens
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.4.2.12
52000
-
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
heart
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
736003
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
2.4.2.12
physiological function
nicotinamide phosphoribosyltransferase is a rate-limiting enzyme in the NAD+ salvage pathway and plays an important role in controlling the level of NAD+ and the activity of Sirt1 in the heart and the cardiomyocytes therein. The enzyme protects the heart from ischemia and reperfusion injury by stimulating Sirt1 and autophagy
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.4.2.12
physiological function
nicotinamide phosphoribosyltransferase is a rate-limiting enzyme in the NAD+ salvage pathway and plays an important role in controlling the level of NAD+ and the activity of Sirt1 in the heart and the cardiomyocytes therein. The enzyme protects the heart from ischemia and reperfusion injury by stimulating Sirt1 and autophagy
Homo sapiens