EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.B38 | Pseudomonas aeruginosa | A0A0H2Z7A3 and A0A0H2Z7K6 | A0A0H2Z7A3 i.e. subunit PqsC, and A0A0H2Z7K6, i.e. subunit PqsB | - |
2.3.1.B38 | Pseudomonas aeruginosa UCBPP-PA14 | A0A0H2Z7A3 and A0A0H2Z7K6 | A0A0H2Z7A3 i.e. subunit PqsC, and A0A0H2Z7K6, i.e. subunit PqsB | - |
2.3.1.230 | Pseudomonas aeruginosa | A0A0H2Z7U1 | cf. EC 2.3.1.180 | - |
2.3.1.230 | Pseudomonas aeruginosa UCBPP-PA14 | A0A0H2Z7U1 | cf. EC 2.3.1.180 | - |
2.3.1.262 | Pseudomonas aeruginosa | P20582 | cf. 2.3.1.230 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.262 | anthraniloyl-CoA + malonyl-CoA | - |
Pseudomonas aeruginosa | 2-aminobenzoylacetyl-CoA + CoA + CO2 | overall reaction | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.B38 | PqsB | - |
Pseudomonas aeruginosa |
2.3.1.B38 | PqsC | - |
Pseudomonas aeruginosa |
2.3.1.230 | PqsD | - |
Pseudomonas aeruginosa |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.B38 | physiological function | 4-hydroxy-2-alkylquinoline biosynthesis, which requires the PqsABCD enzymes, proceeds by a two-step pathway: PqsD mediates the synthesis of 2-aminobenzoylacetate from anthraniloyl-coenzyme A and malonyl-coenzyme A, then the decarboxylating coupling of 2-aminobenzoylacetate to an octanoate group linked to PqsC produces 4-hydroxy-2-heptylquinoline, the direct precursor of 3,4-dihydroxy-2-heptylquinoline. PqsB is tightly associated with PqsC and required for the second step. None of the pqsA-, pqsB-, pqsC-, and pqs- mutants produces measurable amounts of 4-hydroxy-2-alkylquinolines, and PqsB and PqsC have to be present simultaneously to transform the intermediate into 4-hydroxy-2-heptylquinoline | Pseudomonas aeruginosa |
2.3.1.230 | physiological function | 4-hydroxy-2-alkylquinoline biosynthesis, which requires the PqsABCD enzymes, proceeds by a two-step pathway: PqsD mediates the synthesis of 2-aminobenzoylacetate from anthraniloyl-coenzyme A and malonyl-coenzyme A, then the decarboxylating coupling of 2-aminobenzoylacetate to an octanoate group linked to PqsC produces 4-hydroxy-2-heptylquinoline, the direct precursor of 3,4-dihydroxy-2-heptylquinoline. PqsB is tightly associated with PqsC and required for the second step. None of the pqsA-, pqsB-, pqsC-, and pqs- mutants produces measurable amounts of 4-hydroxy-2-alkylquinolines | Pseudomonas aeruginosa |
2.3.1.262 | physiological function | 4-hydroxy-2-alkylquinolines biosynthesis requires the PqsABCD enzymes and proceeds by a two-step pathway: First, PqsD mediates the synthesis of 2-aminobenzoylacetate from anthraniloyl-CoA and malonyl-CoA, then the decarboxylating coupling of 2-aminobenzoylacetate to an octanoate group linked to PqsC produces 4-hydroxy-2-heptylquinoline, the direct precursor of Pseudomonas quinolone signal. PqsB is tightly associated with PqsC and required for the second step | Pseudomonas aeruginosa |