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Literature summary extracted from

  • Neumann, B.; Hilliard, M.A.
    Loss of MEC-17 leads to microtubule instability and axonal degeneration (2014), Cell Rep., 6, 93-103.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.108 Caenorhabditis elegans
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Synonyms

EC Number Synonyms Comment Organism
2.3.1.108 Mec-17
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 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
2.3.1.108 physiological function loss of MEC-17 leads to microtubule instability, a reduction in mitochondrial number, and disrupted axonal transport, with altered distribution of both mitochondria and synaptic components. MEC-17-mediated axonal degeneration occurs independently from its acetyltransferase domain, it is enhanced by mutation of coel-1, a tubulin-associated molecule; and correlates with the animal’s body length Caenorhabditis elegans