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Literature summary extracted from

  • Alam, M.F.; Laskar, A.A.; Choudhary, H.H.; Younus, H.
    Human salivary aldehyde dehydrogenase: purification, kinetic characterization and effect of ethanol, hydrogen peroxide and sodium dodecyl sulfate on the activity of the enzyme (2016), Cell Biochem. Biophys., 74, 307-315.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.5 ethanol 0.05 mM, 1.8fold stimulation Homo sapiens
1.2.1.5 H2O2 0.015 mM, 1.2fold stimulation Homo sapiens
1.2.1.5 Sodium dodecyl sulfate 0.01 mM, 1.1fold stimulation Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.5 0.0007
-
 2-naphthaldehyde pH 7.5, 25°C Homo sapiens
1.2.1.5 0.0033
-
 6-methoxy-2-naphthaldehyde pH 7.5, 25°C Homo sapiens
1.2.1.5 0.0053
-
 cinnamaldehyde pH 7.5, 25°C Homo sapiens
1.2.1.5 0.148
-
 benzaldehyde pH 7.5, 25°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.5 Homo sapiens P30838
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.5 single-step purification Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.5 salivary gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.5 2-naphthaldehyde + NADH + H+
-
 Homo sapiens 2-naphthyl alcohol + NAD+
-
 ?
1.2.1.5 6-methoxy-2-naphthaldehyde + NADH + H+
-
 Homo sapiens (6-methoxynaphthalen-2-yl)methanol + NAD+
-
 ?
1.2.1.5 benzaldehyde + NADH + H+
-
 Homo sapiens benzyl alcohol + NAD+
-
 ?
1.2.1.5 cinnamaldehyde + NADH + H+
-
 Homo sapiens cinnamyl alcohol + NAD+
-
 ?
1.2.1.5 additional information enzyme follows a sequential mode of reaction mechanism Homo sapiens ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.5 45
-
-
 Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.2.1.5 30
-
 2 h, 34% residual activity Homo sapiens
1.2.1.5 50
-
 7 min, almost complete inactivation Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.5 8
-
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.5 NADH
-
 Homo sapiens