EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.4.2.12 | A244M | the mutation prevents inhibitor binding | Homo sapiens |
2.4.2.12 | D219A | inactive | Homo sapiens |
2.4.2.12 | D219S | the mutation leads to a switch in substrate affinity | Homo sapiens |
2.4.2.12 | G217R | the mutation prevents inhibitor binding | Homo sapiens |
2.4.2.12 | G384A | inactive | Homo sapiens |
2.4.2.12 | H191R | the mutation prevents inhibitor binding | Homo sapiens |
2.4.2.12 | H247A | inactive | Homo sapiens |
2.4.2.12 | H247E | the inactive mutant retains the same ability as wild type enzyme in STAT-3 activation, interleukin-6 secretion, macrophage survival following endoplasmic reticulum stress, and M2-polarization | Homo sapiens |
2.4.2.12 | K342R | inactive | Homo sapiens |
2.4.2.12 | Q388R | the mutation prevents dimerization | Homo sapiens |
2.4.2.12 | R311D | the inactive mutant retains the same ability as wild type enzyme in STAT-3 activation, interleukin-6 secretion, macrophage survival following endoplasmic reticulum stress, and M2-polarization | Homo sapiens |
2.4.2.12 | R392A | the inactive mutant retains the same ability as wild type enzyme in STAT-3 activation, interleukin-6 secretion, macrophage survival following endoplasmic reticulum stress, and M2-polarization | Homo sapiens |
2.4.2.12 | S199D | the mutation prevents dimerization and leads to loss of activity | Homo sapiens |
2.4.2.12 | S200D | the mutant retains the same ability as wild type enzyme in STAT-3 activation, interleukin-6 secretion, macrophage survival following endoplasmic reticulum stress, and M2-polarization. The mutation prevents dimerization | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.12 | FK866 | i.e. daporinad, (E)-N-[4-[1-(benzoyl)piperidin-4-yl]butyl]-3-pyridin-3-ylprop-2-enamide | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.4.2.12 | extracellular | - |
Homo sapiens | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.12 | nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | - |
nicotinamide D-ribonucleotide + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.2.12 | Homo sapiens | P43490 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.2.12 | 3T3-L1 cell | - |
Homo sapiens | - |
2.4.2.12 | adipocyte | - |
Homo sapiens | - |
2.4.2.12 | amniotic epithelial cell | - |
Homo sapiens | - |
2.4.2.12 | B-16 cell | - |
Homo sapiens | - |
2.4.2.12 | breast cancer cell | - |
Homo sapiens | - |
2.4.2.12 | BT-549 cell | - |
Homo sapiens | - |
2.4.2.12 | cardiomyocyte | - |
Homo sapiens | - |
2.4.2.12 | cervical cancer cell | - |
Homo sapiens | - |
2.4.2.12 | chronic lymphocytic leukemia cell | - |
Homo sapiens | - |
2.4.2.12 | colorectal cancer cell | - |
Homo sapiens | - |
2.4.2.12 | DU-145 cell | - |
Homo sapiens | - |
2.4.2.12 | fibroblast | - |
Homo sapiens | - |
2.4.2.12 | glial cell | - |
Homo sapiens | - |
2.4.2.12 | glioma cell | - |
Homo sapiens | - |
2.4.2.12 | HCT-116 cell | - |
Homo sapiens | - |
2.4.2.12 | HeLa cell | - |
Homo sapiens | - |
2.4.2.12 | Hep-G2 cell | - |
Homo sapiens | - |
2.4.2.12 | hepatoma cell | - |
Homo sapiens | - |
2.4.2.12 | HIB-1B cell | - |
Homo sapiens | - |
2.4.2.12 | HMCB cell | - |
Homo sapiens | - |
2.4.2.12 | Huh-7 cell | - |
Homo sapiens | - |
2.4.2.12 | HUVEC cell | - |
Homo sapiens | - |
2.4.2.12 | LB-24_MEL cell | - |
Homo sapiens | - |
2.4.2.12 | leucocyte | - |
Homo sapiens | - |
2.4.2.12 | LS-180 cell | - |
Homo sapiens | - |
2.4.2.12 | macrophage | - |
Homo sapiens | - |
2.4.2.12 | MCF10A cell | - |
Homo sapiens | - |
2.4.2.12 | MCF7 cell | - |
Homo sapiens | - |
2.4.2.12 | MDA-MB-231 cell | - |
Homo sapiens | - |
2.4.2.12 | MDA-MB-468 cell | - |
Homo sapiens | - |
2.4.2.12 | melanocyte | - |
Homo sapiens | - |
2.4.2.12 | melanoma cell | - |
Homo sapiens | - |
2.4.2.12 | mesothelioma cell | - |
Homo sapiens | - |
2.4.2.12 | MeWo cell | - |
Homo sapiens | - |
2.4.2.12 | monocyte | - |
Homo sapiens | - |
2.4.2.12 | neuroblastoma cell | - |
Homo sapiens | - |
2.4.2.12 | neuron | - |
Homo sapiens | - |
2.4.2.12 | pancreatic beta cell | - |
Homo sapiens | - |
2.4.2.12 | pancreatic islet cell | - |
Homo sapiens | - |
2.4.2.12 | PC-12 cell | - |
Homo sapiens | - |
2.4.2.12 | peripheral blood lymphocyte | - |
Homo sapiens | - |
2.4.2.12 | pre-B cell | - |
Homo sapiens | - |
2.4.2.12 | prostate cancer cell | - |
Homo sapiens | - |
2.4.2.12 | sebocyte | - |
Homo sapiens | - |
2.4.2.12 | SH-SY5Y cell | - |
Homo sapiens | - |
2.4.2.12 | SK-N-BE cell | - |
Homo sapiens | - |
2.4.2.12 | SkMel-28 cell | - |
Homo sapiens | - |
2.4.2.12 | T-47D cell | - |
Homo sapiens | - |
2.4.2.12 | U-87 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.12 | nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | nicotinamide D-ribonucleotide + diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.2.12 | eNAMPT | - |
Homo sapiens |
2.4.2.12 | pre-B cell colony-enhancing factor | - |
Homo sapiens |
2.4.2.12 | Visfatin | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.12 | ATP | - |
Homo sapiens |
EC Number | Organism | Comment | Expression |
---|---|---|---|
2.4.2.12 | Homo sapiens | enzyme expression is decreased by insulin, PI3K and AKT inhibitors, quercetin | down |
2.4.2.12 | Homo sapiens | enzyme expression is increased by Ox-LDL, CTRP3, glucose, rosiglitazone, adipocyte differentiation, ATP, LPS, CoCl2, ischaemia, OGD, anti-CD38 and differentiation in CCL, oxidative stress (H2O2), hypoxia, TNF-alpha, interleukin-1beta, starvation, and C-peptide | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.4.2.12 | physiological function | the enzyme is involved in cancer | Homo sapiens |