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Literature summary extracted from

  • Ree, R.; Myklebust, L.; Thiel, P.; Foyn, H.; Fladmark, K.; Arnesen, T.
    The N-terminal acetyltransferase Naa10 is essential for zebrafish development (2015), Biosci. Rep., 35, e00249.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.255 expressed in Escherichia coli BL21 cells Danio rerio

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.255 acetyl-CoA + DDDIAAL Danio rerio
-
 CoA + N-acetyl-DDDIAAL
-
 ?
2.3.1.255 acetyl-CoA + EEEIAAL Danio rerio best substrate CoA + N-acetyl-EEEIAAL
-
 ?
2.3.1.255 acetyl-CoA + MLGPEGG Danio rerio poor substrate CoA + N-acetyl-MLGPEGG
-
 ?
2.3.1.255 acetyl-CoA + SESSSKS Danio rerio
-
 CoA + N-acetyl-SESSSKS
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.255 Danio rerio Q7T3B8
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.255 HisTrap column chromatography and Superdex 75 gel filtration Danio rerio

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.255 brain strong expression Danio rerio
-
2.3.1.255 eye strong expression Danio rerio
-
2.3.1.255 larva
-
 Danio rerio
-
2.3.1.255 additional information ubiquitous expression with especially strong staining in brain and eye Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.255 acetyl-CoA + DDDIAAL
-
 Danio rerio CoA + N-acetyl-DDDIAAL
-
 ?
2.3.1.255 acetyl-CoA + DDDIAALRWGRPVGRRRRPVRVYP
-
 Danio rerio CoA + Nalpha-acetyl-DDDIAALRWGRPVGRRRRPVRVYP
-
 ?
2.3.1.255 acetyl-CoA + EEEIAAL best substrate Danio rerio CoA + N-acetyl-EEEIAAL
-
 ?
2.3.1.255 acetyl-CoA + EEEIAALRWGRPVGRRRRPVRVYP
-
 Danio rerio CoA + Nalpha-acetyl-EEEIAALRWGRPVGRRRRPVRVYP
-
 ?
2.3.1.255 acetyl-CoA + MLGPEGG poor substrate Danio rerio CoA + N-acetyl-MLGPEGG
-
 ?
2.3.1.255 acetyl-CoA + MLGPEGGRWGRPVGRRRRPVRVYP
-
 Danio rerio CoA + Nalpha-acetyl-MLGPEGGRWGRPVGRRRRPVRVYP
-
 ?
2.3.1.255 acetyl-CoA + SESSSKS
-
 Danio rerio CoA + N-acetyl-SESSSKS
-
 ?
2.3.1.255 acetyl-CoA + SESSSKSRWGRPVGRRRRPVRVYP
-
 Danio rerio CoA + Nalpha-acetyl-SESSSKSRWGRPVGRRRRPVRVYP
-
 ?
2.3.1.255 additional information N-terminal EEEI is acetylated 3fold more than the DDDI substrate, which again is preferred almost 2fold to SESS, the canonical NatA substrate Danio rerio ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.255 ARD homolog a
-
 Danio rerio
2.3.1.255 ARD1
-
 Danio rerio
2.3.1.255 NAA10
-
 Danio rerio
2.3.1.255 Nalpha-acetyltransferase 10
-
 Danio rerio

General Information

EC Number General Information Comment Organism
2.3.1.255 malfunction naa10 morphants display increased lethality, growth retardation and developmental abnormalities like bent axis, abnormal eyes and bent tails Danio rerio
2.3.1.255 physiological function the enzyme is essential for normal development and viability of zebrafish Danio rerio