Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Higashi, E.; Ando, A.; Iwano, S.; Murayama, N.; Yamazaki, H.; Miyamoto, Y.
    Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig (2014), Biopharm. Drug Dispos., 35, 313-320.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Mus musculus
-
-
2.4.1.17 microsome
-
 Rattus norvegicus
-
-
2.4.1.17 microsome
-
 Sus scrofa
-
-
2.4.1.17 microsome
-
 Canis lupus familiaris
-
-
2.4.1.17 microsome
-
 Macaca fascicularis
-
-
2.4.1.17 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+ required Mus musculus
2.4.1.17 Mg2+ required Rattus norvegicus
2.4.1.17 Mg2+ required Sus scrofa
2.4.1.17 Mg2+ required Canis lupus familiaris
2.4.1.17 Mg2+ required Macaca fascicularis
2.4.1.17 Mg2+ required Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Canis lupus familiaris
-
 beagle dogs
-
2.4.1.17 Homo sapiens O60656 gene UGT1A9
-
2.4.1.17 Homo sapiens P16662 gene UGT2B7
-
2.4.1.17 Homo sapiens P19224 gene UGT1A6
-
2.4.1.17 Homo sapiens P22309 gene UGT1A1
-
2.4.1.17 Homo sapiens P22310 gene UGT1A4
-
2.4.1.17 Macaca fascicularis
-
 cynomolgus monkeys
-
2.4.1.17 Mus musculus
-
 ICR mice
-
2.4.1.17 Rattus norvegicus
-
 SD rats
-
2.4.1.17 Sus scrofa
-
 Yucatan minipig
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Mus musculus
-
2.4.1.17 liver
-
 Rattus norvegicus
-
2.4.1.17 liver
-
 Canis lupus familiaris
-
2.4.1.17 liver
-
 Macaca fascicularis
-
2.4.1.17 liver
-
 Homo sapiens
-
2.4.1.17 liver UGT activities in the microminipig are similar to those in the minipig Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.17 additional information
-
 hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Mus musculus
2.4.1.17 additional information
-
 hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Rattus norvegicus
2.4.1.17 additional information
-
 hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Canis lupus familiaris
2.4.1.17 additional information
-
 hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Macaca fascicularis
2.4.1.17 additional information
-
 hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes Sus scrofa
2.4.1.17 additional information
-
 hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 additional information 3'-azido-3'-deoxythymidine-glucuronidation activity is low in the microminipig compared with humans, morphine-3-glucuronidation activity in the microminipig is higher than that in humans Sus scrofa ?
-
 ?
2.4.1.17 additional information 3'-azido-3'-deoxythymidine-glucuronidation activity is low in the microminipig compared with humans, morphine-3-glucuronidation activity in the microminipig is higher than that in humans Homo sapiens ?
-
 ?
2.4.1.17 additional information no activity with imipramine Canis lupus familiaris ?
-
 ?
2.4.1.17 UDP-glucuronate + 17-beta-estradiol
-
 Mus musculus UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + 17-beta-estradiol
-
 Rattus norvegicus UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + 17-beta-estradiol
-
 Canis lupus familiaris UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + 17-beta-estradiol
-
 Macaca fascicularis UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + 17-beta-estradiol
-
 Homo sapiens UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + 17-beta-estradiol high levels of estradiol-3-glucuronidation in microsomes of 1-day-old microminipigs Sus scrofa UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + 3'-azido-3'-deoxythymidine
-
 Mus musculus UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + 3'-azido-3'-deoxythymidine
-
 Rattus norvegicus UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + 3'-azido-3'-deoxythymidine
-
 Sus scrofa UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + 3'-azido-3'-deoxythymidine
-
 Canis lupus familiaris UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + 3'-azido-3'-deoxythymidine
-
 Macaca fascicularis UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + 3'-azido-3'-deoxythymidine
-
 Homo sapiens UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + imipramine
-
 Sus scrofa UDP + imipramine N-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + imipramine specific substrate of UGT1A4 Homo sapiens UDP + imipramine N-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + morphine
-
 Mus musculus UDP + morphine 3-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + morphine
-
 Rattus norvegicus UDP + morphine 3-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + morphine
-
 Sus scrofa UDP + morphine 3-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + morphine
-
 Canis lupus familiaris UDP + morphine 3-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + morphine
-
 Macaca fascicularis UDP + morphine 3-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + morphine
-
 Homo sapiens UDP + morphine 3-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + morphine morphine-3-glucuronidation is a marker of conjugation by human UGT2B7 Homo sapiens UDP + morphine 3-beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + propofol
-
 Mus musculus UDP + propofol beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + propofol
-
 Rattus norvegicus UDP + propofol beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + propofol
-
 Sus scrofa UDP + propofol beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + propofol
-
 Canis lupus familiaris UDP + propofol beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + propofol
-
 Macaca fascicularis UDP + propofol beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + propofol
-
 Homo sapiens UDP + propofol beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + serotonin
-
 Mus musculus UDP + serotonin beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + serotonin
-
 Rattus norvegicus UDP + serotonin beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + serotonin
-
 Sus scrofa UDP + serotonin beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + serotonin
-
 Canis lupus familiaris UDP + serotonin beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + serotonin
-
 Macaca fascicularis UDP + serotonin beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-glucuronate + serotonin
-
 Homo sapiens UDP + serotonin beta-D-glucuronoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Mus musculus
2.4.1.17 UDP-glucuronosyltransferase
-
 Rattus norvegicus
2.4.1.17 UDP-glucuronosyltransferase
-
 Sus scrofa
2.4.1.17 UDP-glucuronosyltransferase
-
 Canis lupus familiaris
2.4.1.17 UDP-glucuronosyltransferase
-
 Macaca fascicularis
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UGT
-
 Mus musculus
2.4.1.17 UGT
-
 Rattus norvegicus
2.4.1.17 UGT
-
 Sus scrofa
2.4.1.17 UGT
-
 Canis lupus familiaris
2.4.1.17 UGT
-
 Macaca fascicularis
2.4.1.17 UGT
-
 Homo sapiens
2.4.1.17 UGT1A1
-
 Homo sapiens
2.4.1.17 UGT1A4
-
 Homo sapiens
2.4.1.17 UGT1A6
-
 Homo sapiens
2.4.1.17 UGT1A9
-
 Homo sapiens
2.4.1.17 UGT2B7
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Mus musculus
2.4.1.17 37
-
 assay at Rattus norvegicus
2.4.1.17 37
-
 assay at Sus scrofa
2.4.1.17 37
-
 assay at Canis lupus familiaris
2.4.1.17 37
-
 assay at Macaca fascicularis
2.4.1.17 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.4
-
 assay at Mus musculus
2.4.1.17 7.4
-
 assay at Rattus norvegicus
2.4.1.17 7.4
-
 assay at Sus scrofa
2.4.1.17 7.4
-
 assay at Canis lupus familiaris
2.4.1.17 7.4
-
 assay at Macaca fascicularis
2.4.1.17 7.4
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.1.17 evolution UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Mus musculus
2.4.1.17 evolution UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Rattus norvegicus
2.4.1.17 evolution UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Sus scrofa
2.4.1.17 evolution UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Canis lupus familiaris
2.4.1.17 evolution UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Macaca fascicularis
2.4.1.17 evolution UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Homo sapiens
2.4.1.17 physiological function glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds Mus musculus
2.4.1.17 physiological function glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds Rattus norvegicus
2.4.1.17 physiological function glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds Sus scrofa
2.4.1.17 physiological function glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds Canis lupus familiaris
2.4.1.17 physiological function glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds Macaca fascicularis
2.4.1.17 physiological function glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds Homo sapiens