EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.20 | expressed in Sf9 insect cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.20 | (trans-4-[4-[(3-benzyl-1,2,4-oxadiazol-5-yl)carbamoyl]phenyl]cyclohexyl)acetic acid | - |
Homo sapiens | |
2.3.1.20 | (trans-4-[4-[(5-benzyl-1,2,4-oxadiazol-3-yl)carbamoyl]phenyl]cyclohexyl)acetic acid | - |
Homo sapiens | |
2.3.1.20 | (trans-4-[4-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl]cyclohexyl)acetic acid | - |
Homo sapiens | |
2.3.1.20 | cis-4-(4-[[5-(cyclopentylamino)-1,3,4-thiadiazol-2-yl]carbamoyl]phenoxy)cyclohexane-1-carboxylic acid | - |
Homo sapiens | |
2.3.1.20 | cis-4-([5-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]pyridin-2-yl]oxy)cyclohexane-1-carboxylic acid | - |
Homo sapiens | |
2.3.1.20 | cis-4-[4-([3-[(3,5-difluorophenyl)methyl]-1,2,4-oxadiazol-5-yl]carbamoyl)phenoxy]cyclohexane-1-carboxylic acid | - |
Homo sapiens | |
2.3.1.20 | cis-4-[4-([5-[(3,5-difluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenoxy]cyclohexane-1-carboxylic acid | - |
Homo sapiens | |
2.3.1.20 | cis-4-[4-([5-[(cyclopentyloxy)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenoxy]cyclohexane-1-carboxylic acid | - |
Homo sapiens | |
2.3.1.20 | cis-4-[4-[(3-benzyl-1,2,4-oxadiazol-5-yl)carbamoyl]phenoxy]cyclohexane-1-carboxylic acid | - |
Homo sapiens | |
2.3.1.20 | cis-4-[4-[(5-anilino-1,3,4-thiadiazol-2-yl)carbamoyl]phenoxy]cyclohexane-1-carboxylic acid | - |
Homo sapiens | |
2.3.1.20 | cis-4-[4-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenoxy]cyclohexane-1-carboxylic acid | - |
Homo sapiens | |
2.3.1.20 | cis-4-[[5-([5-[(3-chlorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)pyridin-2-yl]oxy]cyclohexane-1-carboxylic acid | - |
Homo sapiens | |
2.3.1.20 | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-4-(trans-4-carbamoylcyclohexyl)benzamide | - |
Homo sapiens | |
2.3.1.20 | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-4-(trans-4-[[2-(dimethylamino)ethyl]carbamoyl]cyclohexyl)benzamide | - |
Homo sapiens | |
2.3.1.20 | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-4-(trans-4-[[2-(morpholin-4-yl)ethyl]carbamoyl]cyclohexyl)benzamide | - |
Homo sapiens | |
2.3.1.20 | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-4-[trans-4-[(2,3-dihydroxypropyl)carbamoyl]cyclohexyl]benzamide | - |
Homo sapiens | |
2.3.1.20 | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-4-[trans-4-[(2-hydroxy-2-methylpropyl)carbamoyl]cyclohexyl]benzamide | - |
Homo sapiens | |
2.3.1.20 | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-4-[trans-4-[(2-methoxyethyl)carbamoyl]cyclohexyl]benzamide | - |
Homo sapiens | |
2.3.1.20 | P-7435 | - |
Homo sapiens | |
2.3.1.20 | pradigastat | - |
Homo sapiens | |
2.3.1.20 | trans-4-[4-([5-[(3,5-difluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenoxy]cyclohexane-1-carboxylic acid | - |
Homo sapiens | |
2.3.1.20 | trans-4-[4-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenoxy]cyclohexane-1-carboxylic acid | - |
Homo sapiens | |
2.3.1.20 | [trans-4-(4-[[5-(2-cyclopentylethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl)cyclohexyl]acetic acid | - |
Homo sapiens | |
2.3.1.20 | [trans-4-[4-([5-[(3,5-difluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenyl]cyclohexyl]acetic acid | - |
Homo sapiens | |
2.3.1.20 | [trans-4-[4-([5-[(4-fluorophenyl)methyl]-1,3,4-oxadiazol-2-yl]carbamoyl)phenyl]cyclohexyl]acetic acid | - |
Homo sapiens | |
2.3.1.20 | [trans-4-[4-([5-[(4-fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenyl]cyclohexyl]acetic acid | - |
Homo sapiens | |
2.3.1.20 | [trans-4-[4-([5-[(cyclopentyloxy)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenyl]cyclohexyl]acetic acid | - |
Homo sapiens | |
2.3.1.20 | [trans-4-[4-([5-[2-(oxolan-2-yl)ethyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenyl]cyclohexyl]acetic acid | - |
Homo sapiens | |
2.3.1.20 | [trans-4-[4-([5-[2-(oxolan-3-yl)ethyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenyl]cyclohexyl]acetic acid | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.20 | octanoyl-CoA + 1,2-di-(cis-9-octadecenoyl)-sn-glycerol | Homo sapiens | - |
CoA + 1,2-di-(cis-9-octadecenoyl)-3-octanoyl-sn-glycerol | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.20 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.20 | octanoyl-CoA + 1,2-di-(cis-9-octadecenoyl)-sn-glycerol | - |
Homo sapiens | CoA + 1,2-di-(cis-9-octadecenoyl)-3-octanoyl-sn-glycerol | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.20 | DGAT-1 | - |
Homo sapiens |
2.3.1.20 | diacylglycerol acyltransferase type 1 | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.20 | 0.000004 | - |
at pH 7.4 and 37°C | Homo sapiens | cis-4-[4-[(5-anilino-1,3,4-thiadiazol-2-yl)carbamoyl]phenoxy]cyclohexane-1-carboxylic acid | |
2.3.1.20 | 0.000009 | - |
at pH 7.4 and 37°C | Homo sapiens | [trans-4-[4-([5-[(3,5-difluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenyl]cyclohexyl]acetic acid | |
2.3.1.20 | 0.000011 | - |
at pH 7.4 and 37°C | Homo sapiens | cis-4-[4-([5-[(3,5-difluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenoxy]cyclohexane-1-carboxylic acid | |
2.3.1.20 | 0.000012 | - |
at pH 7.4 and 37°C | Homo sapiens | cis-4-[4-([5-[(cyclopentyloxy)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenoxy]cyclohexane-1-carboxylic acid | |
2.3.1.20 | 0.000016 | - |
at pH 7.4 and 37°C | Homo sapiens | cis-4-[4-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenoxy]cyclohexane-1-carboxylic acid | |
2.3.1.20 | 0.000019 | - |
at pH 7.4 and 37°C | Homo sapiens | [trans-4-(4-[[5-(2-cyclopentylethyl)-1,3,4-thiadiazol-2-yl]carbamoyl]phenyl)cyclohexyl]acetic acid | |
2.3.1.20 | 0.000022 | - |
at pH 7.4 and 37°C | Homo sapiens | cis-4-(4-[[5-(cyclopentylamino)-1,3,4-thiadiazol-2-yl]carbamoyl]phenoxy)cyclohexane-1-carboxylic acid | |
2.3.1.20 | 0.000036 | - |
at pH 7.4 and 37°C | Homo sapiens | (trans-4-[4-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl]cyclohexyl)acetic acid | |
2.3.1.20 | 0.000038 | - |
at pH 7.4 and 37°C | Homo sapiens | [trans-4-[4-([5-[(cyclopentyloxy)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenyl]cyclohexyl]acetic acid | |
2.3.1.20 | 0.000045 | - |
at pH 7.4 and 37°C | Homo sapiens | cis-4-([5-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]pyridin-2-yl]oxy)cyclohexane-1-carboxylic acid | |
2.3.1.20 | 0.000048 | - |
at pH 7.4 and 37°C | Homo sapiens | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-4-(trans-4-carbamoylcyclohexyl)benzamide | |
2.3.1.20 | 0.000055 | - |
at pH 7.4 and 37°C | Homo sapiens | cis-4-[[5-([5-[(3-chlorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)pyridin-2-yl]oxy]cyclohexane-1-carboxylic acid | |
2.3.1.20 | 0.000057 | - |
at pH 7.4 and 37°C | Homo sapiens | cis-4-[4-[(3-benzyl-1,2,4-oxadiazol-5-yl)carbamoyl]phenoxy]cyclohexane-1-carboxylic acid | |
2.3.1.20 | 0.000081 | - |
at pH 7.4 and 37°C | Homo sapiens | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-4-[trans-4-[(2,3-dihydroxypropyl)carbamoyl]cyclohexyl]benzamide | |
2.3.1.20 | 0.000088 | - |
at pH 7.4 and 37°C | Homo sapiens | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-4-[trans-4-[(2-methoxyethyl)carbamoyl]cyclohexyl]benzamide | |
2.3.1.20 | 0.000092 | - |
at pH 7.4 and 37°C | Homo sapiens | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-4-[trans-4-[(2-hydroxy-2-methylpropyl)carbamoyl]cyclohexyl]benzamide | |
2.3.1.20 | 0.00012 | - |
at pH 7.4 and 37°C | Homo sapiens | cis-4-[4-([3-[(3,5-difluorophenyl)methyl]-1,2,4-oxadiazol-5-yl]carbamoyl)phenoxy]cyclohexane-1-carboxylic acid | |
2.3.1.20 | 0.000122 | - |
at pH 7.4 and 37°C | Homo sapiens | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-4-(trans-4-[[2-(morpholin-4-yl)ethyl]carbamoyl]cyclohexyl)benzamide | |
2.3.1.20 | 0.000144 | - |
at pH 7.4 and 37°C | Homo sapiens | [trans-4-[4-([5-[2-(oxolan-2-yl)ethyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenyl]cyclohexyl]acetic acid | |
2.3.1.20 | 0.00016 | - |
at pH 7.4 and 37°C | Homo sapiens | trans-4-[4-([5-[(3,5-difluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenoxy]cyclohexane-1-carboxylic acid | |
2.3.1.20 | 0.000233 | - |
at pH 7.4 and 37°C | Homo sapiens | [trans-4-[4-([5-[2-(oxolan-3-yl)ethyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenyl]cyclohexyl]acetic acid | |
2.3.1.20 | 0.000253 | - |
at pH 7.4 and 37°C | Homo sapiens | (trans-4-[4-[(3-benzyl-1,2,4-oxadiazol-5-yl)carbamoyl]phenyl]cyclohexyl)acetic acid | |
2.3.1.20 | 0.000279 | - |
at pH 7.4 and 37°C | Homo sapiens | N-(5-benzyl-1,3,4-thiadiazol-2-yl)-4-(trans-4-[[2-(dimethylamino)ethyl]carbamoyl]cyclohexyl)benzamide | |
2.3.1.20 | 0.00028 | - |
at pH 7.4 and 37°C | Homo sapiens | trans-4-[4-[(5-benzyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenoxy]cyclohexane-1-carboxylic acid | |
2.3.1.20 | 0.000286 | - |
at pH 7.4 and 37°C | Homo sapiens | (trans-4-[4-[(5-benzyl-1,2,4-oxadiazol-3-yl)carbamoyl]phenyl]cyclohexyl)acetic acid | |
2.3.1.20 | 0.0006 | - |
at pH 7.4 and 37°C | Homo sapiens | [trans-4-[4-([5-[(4-fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]carbamoyl)phenyl]cyclohexyl]acetic acid | |
2.3.1.20 | 0.00139 | - |
at pH 7.4 and 37°C | Homo sapiens | [trans-4-[4-([5-[(4-fluorophenyl)methyl]-1,3,4-oxadiazol-2-yl]carbamoyl)phenyl]cyclohexyl]acetic acid |