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Literature summary extracted from

  • Kral, K.; Bieg, T.; Nawrot, U.; W?odarczyk, K.; Lalik, A.; Hahn, P.; Wandzik, I.
    New monomeric and dimeric uridinyl derivatives as inhibitors of chitin synthase (2015), Bioorg. Chem., 61, 13-20.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.16 5'-(N-succinyl)-5'-amino-5'-deoxyuridine
-
 Saccharomyces cerevisiae
2.4.1.16 5'-(N-succinyl)-5'-amino-5'-deoxyuridine methyl ester inhibits the yeast enzyme, and exhibits synergistic interaction with caspofungin against Candida albicans Saccharomyces cerevisiae
2.4.1.16 5'-(N-succinylglycyl)-5'-amino-5'-deoxyuridine
-
 Saccharomyces cerevisiae
2.4.1.16 5'-(N-succinylglycyl)-5'-amino-5'-deoxyuridine methyl ester
-
 Saccharomyces cerevisiae
2.4.1.16 5'-deoxy-5'-(glycylamino)uridine
-
 Saccharomyces cerevisiae
2.4.1.16 bis(5'-amino-5'-deoxyuridine) 2,2'-[(1,4-dioxobutane-1,4-diyl)diazanediyl]diacetate 50% inhibition at 3 mM Saccharomyces cerevisiae
2.4.1.16 bis(5'-amino-5'-deoxyuridine) 4-[(carboxymethyl)amino]-4-oxobutanoate
-
 Saccharomyces cerevisiae
2.4.1.16 bis(5'-amino-5'-deoxyuridine) succinate
-
 Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.16 Mg2+ required Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.16 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.16 UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
 Saccharomyces cerevisiae UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.16 25
-
 assay at Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.16 7.5
-
 assay at Saccharomyces cerevisiae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.16 0.8
-
 pH 7.5, 25°C Saccharomyces cerevisiae 5'-(N-succinyl)-5'-amino-5'-deoxyuridine methyl ester