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Literature summary extracted from

  • Meyer-Ficca, M.L.; Ihara, M.; Bader, J.J.; Leu, N.A.; Beneke, S.; Meyer, R.G.
    Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice (2015), Biol. Reprod., 92, 80.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.30 expressed in Mus musculus Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.30 nuclear envelope
-
 Homo sapiens 5635
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.30 additional information Homo sapiens the enzyme has the ability to ADP-ribosylate itself ?
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor Homo sapiens
-
 nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.30 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 additional information the enzyme has the ability to ADP-ribosylate itself Homo sapiens ?
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.30 ADP-ribosyltransferase
-
 Homo sapiens
2.4.2.30 ARTD11
-
 Homo sapiens
2.4.2.30 mono(ADP-ribosyl) transferase
-
 Homo sapiens
2.4.2.30 PARP11
-
 Homo sapiens
2.4.2.30 poly(ADP-ribose) polymerase-11
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.4.2.30 malfunction enzyme deletion results in teratozoospermia and male infertility in mice due to the formation of abnormally shaped fertilization-incompetent sperm, despite normal testis weights and sperm counts Homo sapiens
2.4.2.30 physiological function the enzyme displays functional relevance for nuclear envelope stability and nuclear reorganization during spermiogenesis and is important for proper sperm head shaping Homo sapiens