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Literature summary extracted from

  • Irazoqui, F.; Zlocowski, N.; Lorenz, V.; Bennett, E.; Clausen, H.; Nores, G.
    An acetylation site in lectin domain modulates the biological activity of polypeptide GalNAc-transferase-2 (2013), Biol. Chem., 394, 69-77.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.41 expressed in Sf9 insect cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.41 K521Q the mutation enhances the carbohydrate specificity of lectin domain for alpha-GalNAc and results in reduced enzyme activity compared to the wild type enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.41 benzyl N-acetyl-alpha-D-galactosamine
-
 Homo sapiens
2.4.1.41 additional information not inhibited by by D-glucose or UDP-N-acetyl-alpha-D-galactosamine Homo sapiens
2.4.1.41 N-acetyl-alpha-D-galactosamine the acetylated enzyme is strongly inhibited by N-acetyl-alpha-D-galactosamine Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide Homo sapiens
-
 UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.41 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.41 Co2+-charged resin column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.41 UDP-N-acetyl-alpha-D-galactosamine + polypeptide
-
 Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.41 polypeptide GalNAc-transferase-2
-
 Homo sapiens
2.4.1.41 ppGalNAc-T2
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4.1.41 10
-
 acetylated wild type enzyme, at pH 7.4 and 37°C Homo sapiens benzyl N-acetyl-alpha-D-galactosamine
2.4.1.41 15
-
 mutant enzyme K521Q, at pH 7.4 and 37°C Homo sapiens N-acetyl-alpha-D-galactosamine
2.4.1.41 20
-
 acetylated wild type enzyme, at pH 7.4 and 37°C Homo sapiens N-acetyl-alpha-D-galactosamine