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Literature summary extracted from

  • Cookson, T.V.; Evans, G.L.; Castell, A.; Baker, E.N.; Lott, J.S.; Parker, E.J.
    Structures of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase variants reveal the conformational changes that facilitate delivery of the substrate to the active site (2015), Biochemistry, 54, 6082-6092.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.2.18 mutant enzymes N138A, P180A, R193L, R193A, R194A, and G107P, hanging drop vapor diffusion method, using Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.18 R193L inactive Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.18 anthranilate substrate inhibition Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.18 Mg2+ dependent on Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.18 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate Mycobacterium tuberculosis
-
 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?
2.4.2.18 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate Mycobacterium tuberculosis H37Rv
-
 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.18 Mycobacterium tuberculosis P9WFX5
-
-
2.4.2.18 Mycobacterium tuberculosis H37Rv P9WFX5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.18 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 Mycobacterium tuberculosis anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?
2.4.2.18 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 Mycobacterium tuberculosis H37Rv anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.18 AnPRT
-
 Mycobacterium tuberculosis