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Literature summary extracted from

  • Yu, J.H.; Lee, Y.J.; Kim, H.J.; Choi, H.; Choi, Y.; Seok, J.W.; Kim, J.W.
    Monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor gamma in human hepatocytes and increases lipid accumulation (2015), Biochem. Biophys. Res. Commun., 460, 715-720.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.22 MGAT1 gene expression analysis by real-time PCR, the MGAT1 promoter is highly regulated by PPARgamma, phylogenetic analysis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.22 additional information gene silencing of MGAT1 by siRNA Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.22 Homo sapiens Q96PD6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.22 hepatocyte primary Homo sapiens
-
2.3.1.22 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.22 acyl-CoA + 2-acylglycerol
-
 Homo sapiens CoA + diacylglycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.22 MGAT
-
 Homo sapiens
2.3.1.22 MGAT1
-
 Homo sapiens
2.3.1.22 monoacylglycerol O-acyltransferase
-
 Homo sapiens
2.3.1.22 monoacylglycerol O-acyltransferase 1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.3.1.22 Homo sapiens isozyme MGAT1 is highly induced up to 10fold by peroxisome proliferator-activated receptor gamma, PPARgamma, overexpression in human primary hepatocytes up

General Information

EC Number General Information Comment Organism
2.3.1.22 evolution three subtypes of monoacylglycerol O-acyltransferase, MGAT, enzymes, MGAT1, MGAT2, and MGAT3: in a phylogenetic tree with inferred evolutionary relationships, MGAT3 shares higher sequence homology with the diacylglycerol O-acyltransferase 2 enzyme than with MGAT1 or MGAT2, phylogenetic analysis Homo sapiens
2.3.1.22 malfunction the enzyme is involved in hepatic steatosis, characterized by an increase in intrahepatic triacylglycerol, is an important marker of metabolic dysfunction and is associated closely with insulin resistance and dyslipidemia. Inhibition of MGAT1 ameliorates hepatic steatosis in human liver Hep-G2 cell line, inhibition of MGAT1 by siRNA treatment efficiently ameliorates the lipid accumulation Homo sapiens
2.3.1.22 metabolism the enzyme is involved in triglyceride synthesis by catalyzing the formation of diacylglycerol from monoacylglycerol and fatty acyl CoAs Homo sapiens
2.3.1.22 physiological function monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor gamma in human hepatocytes and increases lipid accumulation Homo sapiens