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Literature summary extracted from

  • Miyata, M.; Ichihara, M.; Tajima, O.; Sobue, S.; Kambe, M.; Sugiura, K.; Furukawa, K.; Furukawa, K.
    UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor alpha and interleukin 6 (2014), Biochem. Biophys. Res. Commun., 445, 504-510.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.92 gene B4GALNT1, quantitative enzyme expression analysis, mRNA expressions of glycosyltransferases by qRT-PCR in melanocytes and melanoma lines, overview Homo sapiens
2.4.3.8 gene ST8SIA1, quantitative enzyme expression analysis, mRNA expressions of glycosyltransferases by qRT-PCR in melanocytes and melanoma lines, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 Homo sapiens
-
 UDP + ganglioside GM2
-
 ?
2.4.3.8 CMP-N-acetylneuraminate + ganglioside GM3 Homo sapiens
-
 CMP + ganglioside GD3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.92 Homo sapiens Q00973 gene B4GALNT1
-
2.4.3.8 Homo sapiens Q92185 gene ST8SIA1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.92 melanocyte
-
 Homo sapiens
-
2.4.1.92 melanoma cell high expression level Homo sapiens
-
2.4.1.92 MeWo cell
-
 Homo sapiens
-
2.4.1.92 SK-MEL-23 cell
-
 Homo sapiens
-
2.4.1.92 SK-MEL-28 cell
-
 Homo sapiens
-
2.4.1.92 SK-MEL-37 cell
-
 Homo sapiens
-
2.4.3.8 melanocyte
-
 Homo sapiens
-
2.4.3.8 melanoma cell
-
 Homo sapiens
-
2.4.3.8 MeWo cell
-
 Homo sapiens
-
2.4.3.8 SK-MEL-23 cell
-
 Homo sapiens
-
2.4.3.8 SK-MEL-28 cell
-
 Homo sapiens
-
2.4.3.8 SK-MEL-37 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3
-
 Homo sapiens UDP + ganglioside GM2
-
 ?
2.4.3.8 CMP-N-acetylneuraminate + ganglioside GM3
-
 Homo sapiens CMP + ganglioside GD3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.92 beta-1,4 N-acetylgalactosaminyltransferase 1 UniProt Homo sapiens
2.4.1.92 GM2/GD2 synthase
-
 Homo sapiens
2.4.3.8 ganglioside GD3 synthase
-
 Homo sapiens
2.4.3.8 GD3 synthase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.1.92 Homo sapiens enzyme expression levels are reduced after UVB irradiation in SK-MEL-28 melanoma cells down
2.4.1.92 Homo sapiens tumor necrosis factor alpha and interleukin 6 do not affect the enzyme expression in in melanocytes additional information
2.4.1.92 Homo sapiens GM2/GD2 synthase expression is slightly increased in UVB-irradiated melanocytes, except for SK-MEL-28 cells up
2.4.3.8 Homo sapiens enzyme expression levels are reduced after UVB irradiation in SK-MEL-28 melanoma cells down
2.4.3.8 Homo sapiens GD3 synthase expression is induced by tumor necrosis factor alpha and interleukin 6 in melanocytes, except for SK-MEL-28 cells up

General Information

EC Number General Information Comment Organism
2.4.1.92 metabolism the enzyme is part of the biosynthetic pathway of glycosphingolipids, overview Homo sapiens
2.4.1.92 additional information UVB-irradiation of keratinocytes induces melanoma-associated ganglioside GM2/GD2 synthase gene in melanocytes via secretion of tumor necrosis factor alpha and interleukin 6 Homo sapiens
2.4.3.8 metabolism the enzyme is part of the biosynthetic pathway of glycosphingolipids, overview Homo sapiens
2.4.3.8 additional information direct UVB-irradiation of keratinocytes does not induces melanoma-associated ganglioside GD3 synthase gene in melanocytes, but UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor a and interleukin 6 Homo sapiens