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Literature summary extracted from

  • Aguilar-Espinosa, S.L.; Mendoza-Espinosa, P.; Delgado-Coello, B.; Mas-Oliva, J.
    Lecithin cholesterol acyltransferase (LCAT) activity in the presence of Apo-AI-derived peptides exposed to disorder-order conformational transitions (2013), Biochem. Biophys. Res. Commun., 441, 469-475.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 apolipoprotein A-I association of Apo AI with HDLs activates LCAT activity, molecular mechanism, conformational changes in several exposed regions of Apo-AI might cause enzyyme LCAT activation. Apo AI-derived peptides display a disordered arrangement, with a strong tendency to adopt beta-sheet and random conformational structures as a function of concentration, but in the presence of lyso-C12-phosphocholine, maximal percentages of alpha-helical structures are observed Homo sapiens
2.3.1.43 additional information peptides, initially present in a disordered conformation, are able to sense the lipid environment provided by lipoproteins of plasma and following a disorder-to-order transition, change their conformation to an ordered alpha-helix Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 phosphatidylcholine + a sterol Homo sapiens
-
 1-acylglycerophosphocholine + a sterol ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens P04180 gene lcat
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.43 additional information
-
 enzyme activities with apolipoprotein A-I and Apo AI-derived peptides DRV, KLL, and VLES, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 phosphatidylcholine + a sterol
-
 Homo sapiens 1-acylglycerophosphocholine + a sterol ester
-
 ?
2.3.1.43 phosphatidylcholine + a sterol enzyme activities with apolipoprotein A-I and Apo AI-derived peptides DRV, KLL, and VLES, overview Homo sapiens 1-acylglycerophosphocholine + a sterol ester
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Homo sapiens
2.3.1.43 lecithin cholesterol acyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.43 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.43 7.4
-
 assay at Homo sapiens