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Literature summary extracted from

  • Zhuo, W.; Chu, F.; Kong, L.; Tao, H.; Sima, Y.; Xu, S.
    Chitin synthase B: a midgut-specific gene induced by insect hormones and involved in food intake in Bombyx mori larvae (2014), Arch. Insect Biochem. Physiol., 85, 36-47.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.1.16 agriculture the enzyme is a specific target of insecticides Bombyx mori

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.16 gene BmChsB, DNA and amino acid sequence determination and analysis, seqeunce comparisons, quantitative expression analysis and expression profile Bombyx mori

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.16 additional information gene BmChsB RNA interfering analysis, overview Bombyx mori

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.16 nikkomycin Z exposure to nikkomycin Z, a CHS inhibitor, reduces the amount of chitin in the peritrophic membrane of molted larvae Bombyx mori

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.16 123884
-
 x * 123884, sequence calculation Bombyx mori

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.16 Bombyx mori Q9GV28 gene BmChsB
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.16 integument lower enzyme level Bombyx mori
-
2.4.1.16 larva
-
 Bombyx mori
-
2.4.1.16 midgut
-
 Bombyx mori
-
2.4.1.16 additional information gene BmChsB expression profiles in the midgut during molting and the mulberry-leaf ingestion processes Bombyx mori
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.16 UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
 Bombyx mori UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.16 ? x * 123884, sequence calculation Bombyx mori

Synonyms

EC Number Synonyms Comment Organism
2.4.1.16 CHS B
-
 Bombyx mori

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.4.1.16 Bombyx mori sequence calculation
-
 7.29

Expression

EC Number Organism Comment Expression
2.4.1.16 Bombyx mori exogenous 20-hydroxyecdysone and methoprene, a juvenile hormone analogue, significantly upregulate the expression of BmChsB when the levels of endogenous molting hormone are low and the levels of endogenous juvenile hormone are high immediately after molting. When levels of endogenous molting hormone are high and those of endogenous juvenile hormone are low during the molting stage, exogenous 20-hydroxyecdyson does not upregulate BmChsB expression and exogenous methoprene upregulates it negligibly. When the endogenous hormone levels are low during the mulberry-leaf intake process, BmChsB expression is upregulated by exogenous methoprene up

General Information

EC Number General Information Comment Organism
2.4.1.16 malfunction exposure to nikkomycin Z, a CHS inhibitor, reduces the amount of chitin in the peritrophic membrane of molted larvae Bombyx mori
2.4.1.16 physiological function chitin synthase is the key regulatory enzyme in chitin synthesis and excretion in insects, and a specific target of insecticides. Expression of BmChsB is regulated by insect hormones, and directly affects the chitin-synthesis-dependent form of the peritrophic membrane and protects the food intake and molting process of silkworm larvae. Gene BmChsB is a midgut-specific gene induced by insect hormones and involved in protecting the food intake of Bombyx mori larvae Bombyx mori