Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Li, Y.; Green, K.D.; Johnson, B.R.; Garneau-Tsodikova, S.
    Inhibition of aminoglycoside acetyltransferase resistance enzymes by metal salts (2015), Antimicrob. Agents Chemother., 59, 4148-4156.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.82 Au3+
-
Pseudomonas aeruginosa
2.3.1.82 Cd2+
-
Pseudomonas aeruginosa
2.3.1.82 Zn2+
-
Pseudomonas aeruginosa
2.3.1.82 Zn2+
-
Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.82 Pseudomonas aeruginosa Q8RPU6
-
-
2.3.1.82 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.82 acetyl-CoA + amikacin
-
Pseudomonas aeruginosa CoA + N6'-acetylamikacin
-
?
2.3.1.82 acetyl-CoA + sisomicin
-
Staphylococcus aureus CoA + N6'-acetylsisomicin
-
?
2.3.1.82 acetyl-CoA + sisomicin
-
Pseudomonas aeruginosa CoA + N6'-acetylsisomicin
-
?
2.3.1.82 acetyl-CoA + tobramicin
-
Staphylococcus aureus CoA + N6'-acetyltobramicin
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.82 aac(3)-Ib/aac(6')-Ib
-
Pseudomonas aeruginosa
2.3.1.82 AAC(6')-Ie/APH(2')-Ia
-
Staphylococcus aureus
2.3.1.82 aminoglycoside (3) acetyltransferase AAC(3)-Ia
-
Pseudomonas aeruginosa
2.3.1.82 aminoglycoside 3-N-acetyltransferase/aminoglycoside 6'-N-acetyltransferase fusion protein
-
Pseudomonas aeruginosa

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.82 0.00041
-
substrate amikacin, pH 6.6, 25°C Pseudomonas aeruginosa Cd2+
2.3.1.82 0.00041
-
substrate amikacin, pH 6.6, 25°C Pseudomonas aeruginosa Au3+
2.3.1.82 0.0052
-
substrate tobramicin, pH 6.6, 25°C Staphylococcus aureus Zn2+
2.3.1.82 0.0078
-
substrate sisomicin, pH 6.6, 25°C Pseudomonas aeruginosa Zn2+
2.3.1.82 0.041
-
substrate sisomicin, pH 6.6, 25°C Staphylococcus aureus Zn2+