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Literature summary extracted from
- Cloning and characterization of histone deacetylase from Babesia bovis (2012), Vet. Parasitol., 190, 423-433.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.5.1.98 | drug development | the enzyme might be a promising target for the development of novel anti-babesial drugs | Babesia bovis |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.5.1.98 | DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of GST-tagged isozyme HDAC3 in Escherichia coli | Babesia bovis |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.98 | cyclo (N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl) | i.e. apicidin, a cyclic tetrapeptide having broad-spectrum antiparasitic activity, inhibits the enzyme activity as well as the in vitro growth of Babesia parasites with an IC50 of 3.8 ng/ml | Babesia bovis |  |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.98 | Zn2+ | required, enzyme bound | Babesia bovis | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.98 | 51200 | - |
x * 51200, isozyme HDAC3, SDS-PAGE, x * 77200, recombinant GST-tagged isozyme HDAC3, SDS-PAGE | Babesia bovis |
| 3.5.1.98 | 77200 | - |
x * 51200, isozyme HDAC3, SDS-PAGE, x * 77200, recombinant GST-tagged isozyme HDAC3, SDS-PAGE | Babesia bovis |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.98 | Babesia bovis | - |
isozyme HDAC3 | - |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.5.1.98 | ? | x * 51200, isozyme HDAC3, SDS-PAGE, x * 77200, recombinant GST-tagged isozyme HDAC3, SDS-PAGE | Babesia bovis |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.1.98 | HDAC | - |
Babesia bovis |
| 3.5.1.98 | HDAC 3 | - |
Babesia bovis |
| 3.5.1.98 | HDAC3 | - |
Babesia bovis |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.98 | 37 | - |
assay at | Babesia bovis |
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Release 2023.1 (January 2023)
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