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Literature summary extracted from

  • Likhite, N.; Jackson, C.A.; Liang, M.S.; Krzyzanowski, M.C.; Lei, P.; Wood, J.F.; Birkaya, B.; Michaels, K.L.; Andreadis, S.T.; Clark, S.D.; Yu, M.C.; Ferkey, D.M.
    The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling (2015), Sci. Signal., 8, ra115.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.320 expression in Escherichia coli Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.320 Caenorhabditis elegans P46580
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-
2.1.1.320 Homo sapiens O14744
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.320 2 S-adenosyl-L-methionine + [D2 dopamine receptor]-L-arginine recombinant fragment of the third intracellular loop of D2, corresponding to amino acid residues 211 to 241 fused to glutathione S-transferase. Residues Arg217 and Arg219 are key methylation sites within this region Homo sapiens 2 S-adenosyl-L-homocysteine + [D2 dopamine receptor]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2.1.1.320 2 S-adenosyl-L-methionine + [DOP-3 receptor]-L-arginine recombinant fragment of the third intracellular loop of Caenorhabditis elegans DOP-3, amino acid residues 202 to 232 fused to GST. Residues Arg208 and Arg210 are key methylation sites within this region Homo sapiens 2 S-adenosyl-L-homocysteine + [DOP-3 receptor]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?

General Information

EC Number General Information Comment Organism
2.1.1.320 physiological function Caenorhabditis elegans lacking PRMT-5 are hypersensitive to dilute octanol. PRMT-5 contributes to the regulation of locomotion by both exogenous and endogenous dopamine Caenorhabditis elegans