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Literature summary extracted from

  • Lioy, V.S.; Goussard, S.; Guerineau, V.; Yoon, E.J.; Courvalin, P.; Galimand, M.; Grillot-Courvalin, C.
    Aminoglycoside resistance 16S rRNA methyltransferases block endogenous methylation, affect translation efficiency and fitness of the host (2014), RNA, 20, 382-391.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.178 16S rRNA methyltransferase NpmA
-
 Escherichia coli
2.1.1.179 16S rRNA methyltransferase ArmA
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.178 S-adenosyl-L-methionine + cytosine1407 in 16S rRNA Escherichia coli
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1407 in 16S rRNA
-
 ?
2.1.1.178 S-adenosyl-L-methionine + cytosine1407 in 16S rRNA Escherichia coli BW25113
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1407 in 16S rRNA
-
 ?
2.1.1.178 S-adenosyl-L-methionine + cytosine1407 in 16S rRNA Escherichia coli MM294
-
 S-adenosyl-L-homocysteine + 5-methylcytosine1407 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA Escherichia coli
-
 S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA Escherichia coli BW25113
-
 S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA Escherichia coli MM294
-
 S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.198 S-adenosyl-L-methionine + cytidine1402 in 16S rRNA Escherichia coli
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
 ?
2.1.1.198 S-adenosyl-L-methionine + cytidine1402 in 16S rRNA Escherichia coli BW25113
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
 ?
2.1.1.198 S-adenosyl-L-methionine + cytidine1402 in 16S rRNA Escherichia coli MM294
-
 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
 ?
2.1.1.199 S-adenosyl-L-methionine + cytosine1402 in 16S rRNA Escherichia coli
-
 S-adenosyl-L-homocysteine + N4-methylcytosine1402 in 16S rRNA
-
 ?
2.1.1.199 S-adenosyl-L-methionine + cytosine1402 in 16S rRNA Escherichia coli BW25113
-
 S-adenosyl-L-homocysteine + N4-methylcytosine1402 in 16S rRNA
-
 ?
2.1.1.199 S-adenosyl-L-methionine + cytosine1402 in 16S rRNA Escherichia coli MM294
-
 S-adenosyl-L-homocysteine + N4-methylcytosine1402 in 16S rRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.178 Escherichia coli
-
-
-
2.1.1.178 Escherichia coli MM294
-
-
-
2.1.1.179 Escherichia coli
-
-
-
2.1.1.179 Escherichia coli MM294
-
-
-
2.1.1.198 Escherichia coli
-
-
-
2.1.1.198 Escherichia coli BW25113
-
-
-
2.1.1.199 Escherichia coli
-
-
-
2.1.1.199 Escherichia coli BW25113
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.178 S-adenosyl-L-methionine + cytosine1407 in 16S rRNA
-
 Escherichia coli S-adenosyl-L-homocysteine + 5-methylcytosine1407 in 16S rRNA
-
 ?
2.1.1.178 S-adenosyl-L-methionine + cytosine1407 in 16S rRNA
-
 Escherichia coli BW25113 S-adenosyl-L-homocysteine + 5-methylcytosine1407 in 16S rRNA
-
 ?
2.1.1.178 S-adenosyl-L-methionine + cytosine1407 in 16S rRNA
-
 Escherichia coli MM294 S-adenosyl-L-homocysteine + 5-methylcytosine1407 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA
-
 Escherichia coli S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA
-
 Escherichia coli BW25113 S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA
-
 Escherichia coli MM294 S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.198 S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
-
 Escherichia coli S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
 ?
2.1.1.198 S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
-
 Escherichia coli BW25113 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
 ?
2.1.1.198 S-adenosyl-L-methionine + cytidine1402 in 16S rRNA
-
 Escherichia coli MM294 S-adenosyl-L-homocysteine + 2'-O-methylcytidine1402 in 16S rRNA
-
 ?
2.1.1.199 S-adenosyl-L-methionine + cytosine1402 in 16S rRNA
-
 Escherichia coli S-adenosyl-L-homocysteine + N4-methylcytosine1402 in 16S rRNA
-
 ?
2.1.1.199 S-adenosyl-L-methionine + cytosine1402 in 16S rRNA
-
 Escherichia coli BW25113 S-adenosyl-L-homocysteine + N4-methylcytosine1402 in 16S rRNA
-
 ?
2.1.1.199 S-adenosyl-L-methionine + cytosine1402 in 16S rRNA
-
 Escherichia coli MM294 S-adenosyl-L-homocysteine + N4-methylcytosine1402 in 16S rRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.178 RsmF
-
 Escherichia coli
2.1.1.179 G1405 methyltransferase ArmA
-
 Escherichia coli
2.1.1.198 RsmI
-
 Escherichia coli
2.1.1.199 RsmH
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
2.1.1.178 malfunction lack of enzyme does not entail a fitness cost to the host Escherichia coli
2.1.1.198 malfunction enzyme deletion affects efficiency of non-AUG initiation and the fidelity of translation Escherichia coli
2.1.1.199 malfunction enzyme deletion affects efficiency of non-AUG initiation and the fidelity of translation Escherichia coli