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Literature summary extracted from

  • Gutierrez, B.; Douthwaite, S.; Gonzalez-Zorn, B.
    Indigenous and acquired modifications in the aminoglycoside binding sites of Pseudomonas aeruginosa rRNAs (2013), RNA Biol., 10, 1324-1332.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA Pseudomonas aeruginosa
-
 S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA Pseudomonas aeruginosa BB1285
-
 S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.193 S-adenosyl-L-methionine + uracil1498 in 16S rRNA Pseudomonas aeruginosa
-
 S-adenosyl-L-homocysteine + N3-methyluracil1498 in 16S rRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.179 Pseudomonas aeruginosa
-
-
-
2.1.1.179 Pseudomonas aeruginosa BB1285
-
-
-
2.1.1.193 Pseudomonas aeruginosa Q9I694
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA
-
 Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.179 S-adenosyl-L-methionine + guanine1405 in 16S rRNA
-
 Pseudomonas aeruginosa BB1285 S-adenosyl-L-homocysteine + N7-methylguanine1405 in 16S rRNA
-
 ?
2.1.1.193 S-adenosyl-L-methionine + uracil1498 in 16S rRNA
-
 Pseudomonas aeruginosa S-adenosyl-L-homocysteine + N3-methyluracil1498 in 16S rRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.179 RmtD
-
 Pseudomonas aeruginosa
2.1.1.193 PA0419
-
 Pseudomonas aeruginosa
2.1.1.193 RsmE
-
 Pseudomonas aeruginosa

General Information

EC Number General Information Comment Organism
2.1.1.179 physiological function the enzyme confers high-level resistance to aminoglycosides Pseudomonas aeruginosa