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Literature summary extracted from

  • Bobenchik, A.M.; Witola, W.H.; Augagneur, Y.; Nic Lochlainn, L.; Garg, A.; Pachikara, N.; Choi, J.Y.; Zhao, Y.O.; Usmani-Brown, S.; Lee, A.; Adjalley, S.H.; Samanta, S.; Fidock, D.A.; Voelker, D.R.; Fikrig, E.; Ben Mamoun, C.
    Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission (2013), Proc. Natl. Acad. Sci. USA, 110, 18262-18267.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.103 NSC-109268
-
 Plasmodium falciparum
2.1.1.103 NSC-125034
-
 Plasmodium falciparum
2.1.1.103 NSC-150080
-
 Plasmodium falciparum
2.1.1.103 NSC-158011 competitive inhibitor Plasmodium falciparum
2.1.1.103 NSC-22225
-
 Plasmodium falciparum
2.1.1.103 NSC-310551
-
 Plasmodium falciparum
2.1.1.103 NSC-323241
-
 Plasmodium falciparum
2.1.1.103 NSC-348401
-
 Plasmodium falciparum
2.1.1.103 NSC-39225
-
 Plasmodium falciparum
2.1.1.103 NSC-641296
-
 Plasmodium falciparum
2.1.1.103 NSC-668394
-
 Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.103 membrane
-
 Plasmodium falciparum 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.103 S-adenosyl-L-methionine + ethanolamine phosphate Plasmodium falciparum
-
 S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.103 Plasmodium falciparum Q8IDQ9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.103 S-adenosyl-L-methionine + ethanolamine phosphate
-
 Plasmodium falciparum S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.103 phosphoethanolamine methyltransferase
-
 Plasmodium falciparum
2.1.1.103 PMT
-
 Plasmodium falciparum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.1.103 0.0008
-
 at pH 8.6 and 37°C Plasmodium falciparum NSC-22225
2.1.1.103 0.005
-
 at pH 8.6 and 37°C Plasmodium falciparum NSC-39225

General Information

EC Number General Information Comment Organism
2.1.1.103 malfunction parasites lacking the enzyme are incapable of producing mature gametocytes and are not transmitted to mosquitoes Plasmodium falciparum
2.1.1.103 physiological function the enzyme is required for gametocyte development, maturation, and transmission to mosquitoes Plasmodium falciparum