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Literature summary extracted from

  • Doleschall, M.; Szabo, J.A.; Pazmandi, J.; Szilagyi, A.; Koncz, K.; Farkas, H.; Toth, M.; Igaz, P.; Glaz, E.; Prohaszka, Z.; Korbonits, M.; Racz, K.; Fuest, G.; Patocs, A.
    Common genetic variants of the human steroid 21-hydroxylase gene (CYP21A2) are related to differences in circulating hormone levels (2014), PLoS ONE, 9, e107244.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.16 additional information two CYP21A2 intron 2 haplotype clusters, named c5 and c8, are related to the circulating steroid hormone levels in subjects with non-functioning adrenal incidentaloma Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.16 17-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 11-deoxycortisol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.16 progesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 11-deoxycorticosterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.16 Homo sapiens P08686
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.16 adrenal cortex
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.16 17-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 11-deoxycortisol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.16 progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 11-deoxycorticosterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.16 CYP21A2
-
 Homo sapiens
1.14.14.16 cytochrome P450c21
-
 Homo sapiens
1.14.14.16 Steroid 21-hydroxylase
-
 Homo sapiens